Benzyloxycarbonyl-L-phenylalanyl-L-lysyl-PABC-deacetylcolchicine

Base Information

Chemical Name:Benzyloxycarbonyl-L-phenylalanyl-L-lysyl-PABC-deacetylcolchicine
CAS No.:1279111-08-8
Molecular Formula:C₅₁H₅₇N₅O₁₁
Molecular Weight:916.04
Hs Code.:

Synonyms:Benzyloxycarbonyl-L-phenylalanyl-L-lysyl-PABC-deacetylcolchicine

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Chemical Property of Benzyloxycarbonyl-L-phenylalanyl-L-lysyl-PABC-deacetylcolchicine

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Technology Process of Benzyloxycarbonyl-L-phenylalanyl-L-lysyl-PABC-deacetylcolchicine

There total 13 articles about Benzyloxycarbonyl-L-phenylalanyl-L-lysyl-PABC-deacetylcolchicine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1279111-11-3
C₅₅H₆₁N₅O₁₃

: 1279111-08-8
Benzyloxycarbonyl-L-phenylalanyl-L-lysyl-PABC-deacetylcolchicine

Guidance literature:: With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran;
DOI:10.1021/ml100287y

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: 1279111-08-8
Benzyloxycarbonyl-L-phenylalanyl-L-lysyl-PABC-deacetylcolchicine

Guidance literature:: Multi-step reaction with 6 steps

1: dicyclohexyl-carbodiimide / tetrahydrofuran

2: sodium hydrogencarbonate / 1,2-dimethoxyethane; water

3: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran

4: pyridine / tetrahydrofuran

5: triethylamine / 1-methyl-pyrrolidin-2-one

6: morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran

With morpholine; 4-methyl-morpholine; pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; water;
DOI:10.1021/ml100287y

Reference yield:

: 56-87-1,3506-25-0
L-lysine

: 1279111-08-8
Benzyloxycarbonyl-L-phenylalanyl-L-lysyl-PABC-deacetylcolchicine

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide / water

2: sodium hydrogencarbonate / 1,2-dimethoxyethane; water

3: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran

4: pyridine / tetrahydrofuran

5: triethylamine / 1-methyl-pyrrolidin-2-one

6: morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran

With morpholine; 4-methyl-morpholine; pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; water;
DOI:10.1021/ml100287y