6-(1-benzyl-1H-indol-3-yl)-2-(1-pyrrolidinylmethyl)thieno[3,2-d]pyrimidin-4(3H)-one

Base Information

Chemical Name:6-(1-benzyl-1H-indol-3-yl)-2-(1-pyrrolidinylmethyl)thieno[3,2-d]pyrimidin-4(3H)-one
CAS No.:1440957-74-3
Molecular Formula:C₂₆H₂₄N₄OS
Molecular Weight:440.569
Hs Code.:

Synonyms:6-(1-benzyl-1H-indol-3-yl)-2-(1-pyrrolidinylmethyl)thieno[3,2-d]pyrimidin-4(3H)-one

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Chemical Property of 6-(1-benzyl-1H-indol-3-yl)-2-(1-pyrrolidinylmethyl)thieno[3,2-d]pyrimidin-4(3H)-one

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Technology Process of 6-(1-benzyl-1H-indol-3-yl)-2-(1-pyrrolidinylmethyl)thieno[3,2-d]pyrimidin-4(3H)-one

There total 10 articles about 6-(1-benzyl-1H-indol-3-yl)-2-(1-pyrrolidinylmethyl)thieno[3,2-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1440958-19-9
5-(1-benzyl-1H-indol-3-yl)-3-[(1-pyrrolidinylacetyl)amino]-2-thiophenecarboxamide

: 1440957-74-3
6-(1-benzyl-1H-indol-3-yl)-2-(1-pyrrolidinylmethyl)thieno[3,2-d]pyrimidin-4(3H)-one

Guidance literature:: With sodium hydroxide; In N,N-dimethyl-formamide; for 0.5h; Reflux;
DOI:10.1016/j.ejmech.2013.03.022

Reference yield:

: 703-80-0
3-acetylindole

: 1440957-74-3
6-(1-benzyl-1H-indol-3-yl)-2-(1-pyrrolidinylmethyl)thieno[3,2-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium hydroxide / ethanol / 20 °C

1.2: 0.08 h / 20 °C

2.1: trichlorophosphate / 0.5 h / 0 °C

2.2: 3 h / 0 - 20 °C

2.3: Cooling with ice

3.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 6 h / 60 °C

4.1: di-2-pyridyl thionocarbonate; dmap / dichloromethane / 20 °C

5.1: sodium sulfide nonahydrate / N,N-dimethyl-formamide / 2 h / 50 °C

6.1: N,N-dimethyl-formamide / 2 h / 50 °C

7.1: sodium ethanolate / ethanol / 2 h / 50 °C

8.1: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C

9.1: potassium carbonate / acetonitrile / 1 h / Reflux

10.1: sodium hydroxide / N,N-dimethyl-formamide / 0.5 h / Reflux

With dmap; sodium sulfide nonahydrate; hydroxylamine hydrochloride; sodium ethanolate; sodium acetate; potassium carbonate; di-2-pyridyl thionocarbonate; triethylamine; potassium hydroxide; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 2.1: |Vilsmeier-Haack Formylation / 2.2: |Vilsmeier-Haack Formylation;
DOI:10.1016/j.ejmech.2013.03.022

Reference yield:

: [3-chloro-3-(1-benzyl-1H-indol-3-yl)prop-2-enylidene]dimethyliminium perchlorate

: 1440957-74-3
6-(1-benzyl-1H-indol-3-yl)-2-(1-pyrrolidinylmethyl)thieno[3,2-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 8 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol / 6 h / 60 °C

2: di-2-pyridyl thionocarbonate; dmap / dichloromethane / 20 °C

3: sodium sulfide nonahydrate / N,N-dimethyl-formamide / 2 h / 50 °C

4: N,N-dimethyl-formamide / 2 h / 50 °C

5: sodium ethanolate / ethanol / 2 h / 50 °C

6: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C

7: potassium carbonate / acetonitrile / 1 h / Reflux

8: sodium hydroxide / N,N-dimethyl-formamide / 0.5 h / Reflux

With dmap; sodium sulfide nonahydrate; hydroxylamine hydrochloride; sodium ethanolate; sodium acetate; potassium carbonate; di-2-pyridyl thionocarbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2013.03.022