ethyl 2-(benzo[d][1,3]dioxol-5-yl)-4-hydroxy-5-oxo-1-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylate

Base Information

• Chemical Name: ethyl 2-(benzo[d][1,3]dioxol-5-yl)-4-hydroxy-5-oxo-1-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylate
• CAS No.: 1415676-75-3
• Molecular Formula: C₂₀H₁₇NO₆
• Molecular Weight: 367.358

Synonyms:ethyl 2-(benzo[d][1,3]dioxol-5-yl)-4-hydroxy-5-oxo-1-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylate

Chemical Property of ethyl 2-(benzo[d][1,3]dioxol-5-yl)-4-hydroxy-5-oxo-1-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylate

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Technology Process of ethyl 2-(benzo[d][1,3]dioxol-5-yl)-4-hydroxy-5-oxo-1-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylate

There total 2 articles about ethyl 2-(benzo[d][1,3]dioxol-5-yl)-4-hydroxy-5-oxo-1-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

piperonal (120-57-0,30024-74-9) + aniline (62-53-3) + acetylenedicarboxylic acid diethyl ester (762-21-0) → ethyl 2-(benzo[d][1,3]dioxol-5-yl)-4-hydroxy-5-oxo-1-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylate (1415676-75-3)

Guidance literature:

With 1,1'-butylenebis(3-sulfo-3H-imidazol-1-ium) chloride; In ethanol; at 20 ℃; for 0.5h;

DOI:10.1071/CH18246

Reference yield: 44.0%

piperonal-phenylimine (27738-39-2) + sodium diethylmalonate (996-82-7) → ethyl 2-(benzo[d][1,3]dioxol-5-yl)-4-hydroxy-5-oxo-1-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylate (1415676-75-3)

Guidance literature:

sodium diethylmalonate; With sulfuric acid; water; In diethyl ether; at 0 ℃; for 0.5h;

piperonal-phenylimine; at 20 ℃;

DOI:10.1021/ol302976g

Reference yield: 94.0%

ethyl 2-(benzo[d][1,3]dioxol-5-yl)-4-hydroxy-5-oxo-1-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylate (1415676-75-3) + cyclohexane carbonitrile (766-05-2) + (E)-N-benzylidenebenzenamine (1750-36-3,33993-35-0,538-51-2,137431-97-1,137432-04-3) → ethyl 2-(benzo[d][1,3]dioxol-5-yl)-4-(benzyl(2-(cyclohexylamino)-2-oxo-1-phenylethyl)amino)-5-oxo-1-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylate

Guidance literature:

In methanol; at 26 ℃; for 48h;

DOI:10.1021/ol302976g

upstream raw materials:

piperonal-phenylimine

sodium diethylmalonate

piperonal

aniline

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