2-Fluoro-4-[(2-hydroxymethyl-7-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-N-(3-nitro-benzyl)-benzamide

Base Information

Chemical Name:2-Fluoro-4-[(2-hydroxymethyl-7-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-N-(3-nitro-benzyl)-benzamide
CAS No.:173952-25-5
Molecular Formula:C₂₈H₂₄FN₅O₅
Molecular Weight:529.527
Hs Code.:

Synonyms:2-Fluoro-4-[(2-hydroxymethyl-7-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-N-(3-nitro-benzyl)-benzamide

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Chemical Property of 2-Fluoro-4-[(2-hydroxymethyl-7-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-N-(3-nitro-benzyl)-benzamide

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Technology Process of 2-Fluoro-4-[(2-hydroxymethyl-7-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-N-(3-nitro-benzyl)-benzamide

There total 9 articles about 2-Fluoro-4-[(2-hydroxymethyl-7-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-N-(3-nitro-benzyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 173952-23-3
Acetic acid 6-({[3-fluoro-4-(3-nitro-benzylcarbamoyl)-phenyl]-prop-2-ynyl-amino}-methyl)-7-methyl-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl ester

: 173952-25-5
2-Fluoro-4-[(2-hydroxymethyl-7-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-N-(3-nitro-benzyl)-benzamide

Guidance literature:: With sodium hydroxide; In methanol; for 4h;
DOI:10.1021/jm950645n

Reference yield:

: 7409-18-9
3-nitrobenzylamine

: 173952-25-5
2-Fluoro-4-[(2-hydroxymethyl-7-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-N-(3-nitro-benzyl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / diphenyl phosphorazidate, triethylamine / dimethylformamide / 16 h

2: 60 percent / CaCO₃ / dimethylformamide / 18 h / 80 °C

3: 89 percent / 1 N aq. NaOH / methanol / 4 h

With sodium hydroxide; diphenyl phosphoryl azide; triethylamine; calcium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm950645n

Reference yield:

: 140373-03-1
tert-butyl 2-fluoro-4-(prop-2-ynylamino)benzoate

: 173952-25-5
2-Fluoro-4-[(2-hydroxymethyl-7-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-N-(3-nitro-benzyl)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / CH₂Cl₂ / 3 h

2: 79 percent / diphenyl phosphorazidate, triethylamine / dimethylformamide / 16 h

3: 60 percent / CaCO₃ / dimethylformamide / 18 h / 80 °C

4: 89 percent / 1 N aq. NaOH / methanol / 4 h

With sodium hydroxide; diphenyl phosphoryl azide; triethylamine; trifluoroacetic acid; calcium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm950645n