1-(4-ethylamino-2-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenylamino)-8-phenyl-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-2,2,2-trifluoroethanone

Base Information

Chemical Name:1-(4-ethylamino-2-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenylamino)-8-phenyl-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-2,2,2-trifluoroethanone
CAS No.:1263870-35-4
Molecular Formula:C₂₆H₂₄F₄N₈O
Molecular Weight:540.523
Hs Code.:

1-(4-ethylamino-2-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenylamino)-8-phenyl-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-2,2,2-trifluoroethanone

Synonyms:1-(4-ethylamino-2-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenylamino)-8-phenyl-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-2,2,2-trifluoroethanone

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Chemical Property of 1-(4-ethylamino-2-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenylamino)-8-phenyl-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-2,2,2-trifluoroethanone

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Technology Process of 1-(4-ethylamino-2-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenylamino)-8-phenyl-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-2,2,2-trifluoroethanone

There total 8 articles about 1-(4-ethylamino-2-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenylamino)-8-phenyl-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-2,2,2-trifluoroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1263870-33-2
N₄-ethyl-N₂-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenyl)-8-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine

: 407-25-0
trifluoroacetic anhydride

: 1263870-35-4
1-(4-ethylamino-2-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenylamino)-8-phenyl-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-2,2,2-trifluoroethanone

Guidance literature:: With triethylamine; dmap; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 1263870-35-4
1-(4-ethylamino-2-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenylamino)-8-phenyl-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-2,2,2-trifluoroethanone

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / dimethyl sulfoxide / 48 h / 80 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / Cooling with ice-water

3: sodium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane; water / 24 h / 110 °C / Inert atmosphere

4: trifluorormethanesulfonic acid / toluene / 1 h / Reflux

5: triethylamine / dmap / dichloromethane / 0 - 20 °C

With trifluorormethanesulfonic acid; hydrogen; sodium hydrogencarbonate; sodium carbonate; triethylamine; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; toluene;

Reference yield:

: 1185019-89-9
1-(2-Fluoro-4-nitro-phenyl)-5-methyl-1H-[1,2,4]triazole

: 1263870-35-4
1-(4-ethylamino-2-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenylamino)-8-phenyl-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-2,2,2-trifluoroethanone

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / Cooling with ice-water

2: sodium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane; water / 24 h / 110 °C / Inert atmosphere

3: trifluorormethanesulfonic acid / toluene / 1 h / Reflux

4: triethylamine / dmap / dichloromethane / 0 - 20 °C

With trifluorormethanesulfonic acid; hydrogen; sodium carbonate; triethylamine; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; dichloromethane; water; toluene;