1185019-89-9

Upstream product

• 7170-01-6 3-methyl-1H-[1,2,4]triazole 
• 369-34-6 3,4-difluoronitrobenzene 
• 7170-01-6 5-methyl-1H-1,2,4-triazole 

Downstream Products

• 1185019-91-3 3-fluoro-4-(5-methyl-[1,2,4]triazol-1-yl)-phenylamine 
• 1263870-27-4 N₂-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenyl)-6-(4-methoxybenzyl)-N₄-methyl-8-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine 
• 1263870-28-5 N₄-ethyl-N₂-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenyl)-6-(4-methoxybenzyl)-8-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine 
• 1263870-32-1 N₂-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenyl)-N₄-methyl-8-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine 
• 1263870-33-2 N₄-ethyl-N₂-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenyl)-8-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine 
• 1263870-35-4 1-(4-ethylamino-2-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenylamino)-8-phenyl-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-2,2,2-trifluoroethanone 
• 1263870-52-5 N₄-ethyl-N₂-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenyl)-8-(4-fluorophenyl)-6-(4-methoxybenzyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine 
• 1263870-58-1 N₄-ethyl-N₂-(3-fluoro-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenyl)-8-(4-fluorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine 
• 1356009-10-3 1-(2-(allyloxy)-4-nitrophenyl)-5-methyl-1H-1,2,4-triazole 
• 1356008-34-8 (R)-(11Z)-18-(2,4-difluorophenyl)-7-(5-methyI-1H-1,2,4-triazol-1-yl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecine 
• 1356008-35-9 (S)-(11Z)-18-(2,4-difluorophenyl)-7-(5-methyI-1H-1,2,4-triazol-1-yl)-10,13,14,16,17,18-hexahydro-15,2-(azeno)-8,4-(metheno)cyclopenta[h][1,6,10,12]oxatriazacycloheptadecine 
• 1356009-08-9 3-(allyloxy)-4-(5-methyl-1H-1,2,4-triazol-1-yl)aniline 
• 1356010-52-0 N₄-allyl-N₂-(3-(allyloxy)-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-(2,4-difluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine 
• 1356010-48-4 N₄-allyl-N₂-(3-(allyloxy)-4-(5-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine 

Relevant academic research and scientific papers

COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION

Compounds of the formula (I) are provided, including pharmaceutically acceptable salts thereof: which modulate β-amyloid peptide (β-AP) production, and are useful in the treatment of Alzheimer's Disease and other conditions affected by -amyloid peptide (β-AP) production.

COMPOUNDS FOR THE REDUCTION OF β-AMYLOID PRODUCTION

The present disclosure provides a series of compounds of the formula (I) which modulate β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production.

NOVEL SUBSTITUTED BENZOXAZOLE, BENZIMIDAZOLE, OXAZOLOPYRIDINE AND IMIDAZOPYRIDINE DERIVATIVES AS GAMMA SECRETASE MODULATORS

The present invention is concerned with novel substituted benzoxazole, benzimidazole, oxazolopyridine and imidazopyridine derivatives of Formula (I) wherein R1, R2, R3, R4, X, A1, A2, A3, A4, Y1, Y2, Y3 and Z have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

BICYCLIC COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION

The present disclosure provides a series of compounds of the formula (I) which reduce β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production, wherein

MODULATORS FOR AMYLOID BETA

The invention relates to compounds of formula wherein the substituents are as described in claim 1. Compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposi