3-(tert-butyldimethylsilyloxymethyl)-4-(2-phenylimidazol-1-yl)butanamide

Base Information

Chemical Name:3-(tert-butyldimethylsilyloxymethyl)-4-(2-phenylimidazol-1-yl)butanamide
CAS No.:791856-95-6
Molecular Formula:C₂₀H₃₁N₃O₂Si
Molecular Weight:373.571
Hs Code.:

Synonyms:3-(tert-butyldimethylsilyloxymethyl)-4-(2-phenylimidazol-1-yl)butanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(tert-butyldimethylsilyloxymethyl)-4-(2-phenylimidazol-1-yl)butanamide

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Technology Process of 3-(tert-butyldimethylsilyloxymethyl)-4-(2-phenylimidazol-1-yl)butanamide

There total 6 articles about 3-(tert-butyldimethylsilyloxymethyl)-4-(2-phenylimidazol-1-yl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 791856-93-4
methyl 3-(tert-butyldimethylsilyloxymethyl)-4-(2-phenylimidazol-1-yl)butanoate

: 791856-95-6
3-(tert-butyldimethylsilyloxymethyl)-4-(2-phenylimidazol-1-yl)butanamide

Guidance literature:: With dimethylaluminum chloride; ammonium chloride; In dichloromethane; for 24h; Heating;
DOI:10.1021/jo040193z

Reference yield:

: 80904-75-2
4-hydroxymethyl-5H-furan-2-one

: 791856-95-6
3-(tert-butyldimethylsilyloxymethyl)-4-(2-phenylimidazol-1-yl)butanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 99 percent / H₂ / Pd/C / methanol / 4 h / 20 °C / atmospheric pressure

2.1: 95 percent / imidazole / dimethylformamide / 13 h / 0 - 20 °C

3.1: KH

3.2: 76 percent / 3 h / 160 - 170 °C

4.1: DMAP / CH₂Cl₂ / 0.5 h / 0 °C

4.2: 80 percent / EDCI / CH₂Cl₂ / 5 h / 0 - 20 °C

5.1: 67 percent / AlMe₂Cl; NH₄Cl / CH₂Cl₂ / 24 h / Heating

With 1H-imidazole; dmap; hydrogen; dimethylaluminum chloride; potassium hydride; ammonium chloride; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo040193z

Reference yield:

: 36679-81-9
4-hydroxymethyl-1,2,3,4-tetrahydrofuran-2-one

: 791856-95-6
3-(tert-butyldimethylsilyloxymethyl)-4-(2-phenylimidazol-1-yl)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / imidazole / dimethylformamide / 13 h / 0 - 20 °C

2.1: KH

2.2: 76 percent / 3 h / 160 - 170 °C

3.1: DMAP / CH₂Cl₂ / 0.5 h / 0 °C

3.2: 80 percent / EDCI / CH₂Cl₂ / 5 h / 0 - 20 °C

4.1: 67 percent / AlMe₂Cl; NH₄Cl / CH₂Cl₂ / 24 h / Heating

With 1H-imidazole; dmap; dimethylaluminum chloride; potassium hydride; ammonium chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo040193z