1(R)-(3-cyclohexyl-3(R)-hydroxypropyl)-2,3,3a,4,9,9a-hexahydro-2(R)-<(tert-butyldimethylsilyl)oxy>-5-methoxy-(3aS,9aS)-1H-benzindene

Base Information

Chemical Name:1(R)-(3-cyclohexyl-3(R)-hydroxypropyl)-2,3,3a,4,9,9a-hexahydro-2(R)-<(tert-butyldimethylsilyl)oxy>-5-methoxy-(3aS,9aS)-1H-benzindene
CAS No.:111025-99-1
Molecular Formula:C₂₉H₄₈O₃Si
Molecular Weight:472.784
Hs Code.:

1(R)-(3-cyclohexyl-3(R)-hydroxypropyl)-2,3,3a,4,9,9a-hexahydro-2(R)-<(tert-butyldimethylsilyl)oxy>-5-methoxy-(3aS,9aS)-1H-benz<f>indene

Synonyms:1(R)-(3-cyclohexyl-3(R)-hydroxypropyl)-2,3,3a,4,9,9a-hexahydro-2(R)-<(tert-butyldimethylsilyl)oxy>-5-methoxy-(3aS,9aS)-1H-benzindene

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Chemical Property of 1(R)-(3-cyclohexyl-3(R)-hydroxypropyl)-2,3,3a,4,9,9a-hexahydro-2(R)-<(tert-butyldimethylsilyl)oxy>-5-methoxy-(3aS,9aS)-1H-benzindene

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Technology Process of 1(R)-(3-cyclohexyl-3(R)-hydroxypropyl)-2,3,3a,4,9,9a-hexahydro-2(R)-<(tert-butyldimethylsilyl)oxy>-5-methoxy-(3aS,9aS)-1H-benzindene

There total 1 articles about 1(R)-(3-cyclohexyl-3(R)-hydroxypropyl)-2,3,3a,4,9,9a-hexahydro-2(R)-<(tert-butyldimethylsilyl)oxy>-5-methoxy-(3aS,9aS)-1H-benzindene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.4%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 99511-98-5
15-cyclohexyl-9-deoxy-13,14-dihydro-2',9α-methano-3-oxa-1,4,5,6,16,17,18,19,20-nonanor-3,7-(1',3'-inter-phenylene)-PGF1

: 111025-99-1
1(R)-(3-cyclohexyl-3(R)-hydroxypropyl)-2,3,3a,4,9,9a-hexahydro-2(R)-<(tert-butyldimethylsilyl)oxy>-5-methoxy-(3aS,9aS)-1H-benzindene

: (1R,2R,3aS,9aS)-2-(tert-Butyl-dimethyl-silanyloxy)-1-[(R)-3-(tert-butyl-dimethyl-silanyloxy)-3-cyclohexyl-propyl]-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalene

Guidance literature:: With 1H-imidazole; In tetrahydrofuran; at 0 - 20 ℃; for 96h;
DOI:10.1021/jo00234a016

Reference yield:

: 111025-99-1
1(R)-(3-cyclohexyl-3(R)-hydroxypropyl)-2,3,3a,4,9,9a-hexahydro-2(R)-<(tert-butyldimethylsilyl)oxy>-5-methoxy-(3aS,9aS)-1H-benzindene

: 101691-76-3
1(R)-(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-(3aS,9aS)-1H-benzindene-2(R),5-diol

Guidance literature:: Multi-step reaction with 4 steps

1: 0.33 g / pyridine, water / 24.5 h / 0 - 20 °C

2: 78.9 percent / lithium aluminum hydride / diethyl ether / 24 h / Ambient temperature

3: 90.4 percent / 2 N HCl / propan-2-ol; tetrahydrofuran / 24 h

4: 94.5 percent / diphenylphosphine, n-butyllithium / tetrahydrofuran; hexane / 25 h / 70 °C

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; water; diphenylphosphane; In tetrahydrofuran; diethyl ether; hexane; isopropyl alcohol;
DOI:10.1021/jo00234a016

Reference yield:

: 111025-99-1
1(R)-(3-cyclohexyl-3(R)-hydroxypropyl)-2,3,3a,4,9,9a-hexahydro-2(R)-<(tert-butyldimethylsilyl)oxy>-5-methoxy-(3aS,9aS)-1H-benzindene

: 101691-75-2
1(R)-(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-5-methoxy-(3aS,9aS)-1H-benzinden-2(R)-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 0.33 g / pyridine, water / 24.5 h / 0 - 20 °C

2: 78.9 percent / lithium aluminum hydride / diethyl ether / 24 h / Ambient temperature

3: 90.4 percent / 2 N HCl / propan-2-ol; tetrahydrofuran / 24 h

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; water; In tetrahydrofuran; diethyl ether; isopropyl alcohol;
DOI:10.1021/jo00234a016