[5'-O-triphenylmethyl-2'-deoxy-3'-O-(4-(2-cyclohexylethyl)benzenesulfonyl)-β-D-threopentofuranosyl]thymine

Base Information

Chemical Name:[5'-O-triphenylmethyl-2'-deoxy-3'-O-(4-(2-cyclohexylethyl)benzenesulfonyl)-β-D-threopentofuranosyl]thymine
CAS No.:1262387-16-5
Molecular Formula:C₄₃H₄₆N₂O₇S
Molecular Weight:734.913
Hs Code.:

Synonyms:[5'-O-triphenylmethyl-2'-deoxy-3'-O-(4-(2-cyclohexylethyl)benzenesulfonyl)-β-D-threopentofuranosyl]thymine

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Chemical Property of [5'-O-triphenylmethyl-2'-deoxy-3'-O-(4-(2-cyclohexylethyl)benzenesulfonyl)-β-D-threopentofuranosyl]thymine

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Technology Process of [5'-O-triphenylmethyl-2'-deoxy-3'-O-(4-(2-cyclohexylethyl)benzenesulfonyl)-β-D-threopentofuranosyl]thymine

There total 5 articles about [5'-O-triphenylmethyl-2'-deoxy-3'-O-(4-(2-cyclohexylethyl)benzenesulfonyl)-β-D-threopentofuranosyl]thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1262387-07-4
4-(2-cyclohexyl-ethyl)-benzenesulfonyl chloride

: 55612-11-8
5'-O-trityldeoxyxylothymidine

: 1262387-16-5
[5'-O-triphenylmethyl-2'-deoxy-3'-O-(4-(2-cyclohexylethyl)benzenesulfonyl)-β-D-threopentofuranosyl]thymine

Guidance literature:: With pyridine; silver trifluoromethanesulfonate; at 0 - 20 ℃;

Reference yield:

: 2043-61-0
cyclohexanecarbaldehyde

: 1262387-16-5
[5'-O-triphenylmethyl-2'-deoxy-3'-O-(4-(2-cyclohexylethyl)benzenesulfonyl)-β-D-threopentofuranosyl]thymine

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 8 h / 20 °C

3.1: chlorosulfonic acid; sodium chloride / chloroform / 0 - 20 °C

4.1: pyridine; silver trifluoromethanesulfonate / 0 - 20 °C

With pyridine; chlorosulfonic acid; hydrogen; silver trifluoromethanesulfonate; sodium chloride; lithium diisopropyl amide; palladium 10% on activated carbon; In tetrahydrofuran; chloroform; ethyl acetate;

Reference yield:

: 18869-27-7
(E)-(2-cyclohexylvinyl)benzene

: 1262387-16-5
[5'-O-triphenylmethyl-2'-deoxy-3'-O-(4-(2-cyclohexylethyl)benzenesulfonyl)-β-D-threopentofuranosyl]thymine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 8 h / 20 °C

2: chlorosulfonic acid; sodium chloride / chloroform / 0 - 20 °C

3: pyridine; silver trifluoromethanesulfonate / 0 - 20 °C

With pyridine; chlorosulfonic acid; hydrogen; silver trifluoromethanesulfonate; sodium chloride; palladium 10% on activated carbon; In chloroform; ethyl acetate;