2-[2-(2,2-bis-ethoxycarbonyl-ethyl)-benzyl]malonic acid diethyl ester

Base Information

• Chemical Name: 2-[2-(2,2-bis-ethoxycarbonyl-ethyl)-benzyl]malonic acid diethyl ester
• CAS No.: 69403-16-3
• Molecular Formula: C₂₂H₃₀O₈
• Molecular Weight: 422.475
• Mol file: 69403-16-3.mol

Synonyms:2-[2-(2,2-bis-ethoxycarbonyl-ethyl)-benzyl]malonic acid diethyl ester

Chemical Property of 2-[2-(2,2-bis-ethoxycarbonyl-ethyl)-benzyl]malonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-[2-(2,2-bis-ethoxycarbonyl-ethyl)-benzyl]malonic acid diethyl ester

There total 6 articles about 2-[2-(2,2-bis-ethoxycarbonyl-ethyl)-benzyl]malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

α,α'-dibromo-o-xylene (91-13-4) + diethyl malonate (105-53-3) → 2-[2-(2,2-bis-ethoxycarbonyl-ethyl)-benzyl]malonic acid diethyl ester (69403-16-3)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; for 0.5h; Ambient temperature;

DOI:10.1016/S0040-4020(97)00486-9

Reference yield: 53.0%

o-Xylylene dichloride (612-12-4) + diethyl malonate (105-53-3) → 2-[2-(2,2-bis-ethoxycarbonyl-ethyl)-benzyl]malonic acid diethyl ester (69403-16-3)

Guidance literature:

diethyl malonate; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 18 ℃; for 1h; Inert atmosphere;

o-Xylylene dichloride; In N,N-dimethyl-formamide; at 0 - 70 ℃; for 48h; Solvent; Inert atmosphere;

Reference yield:

α,α'-dibromo-o-xylene (91-13-4) + diethyl malonate (105-53-3) → diethyl indan-2,2-dicarboxylate (66014-45-7) + 2-[2-(2,2-bis-ethoxycarbonyl-ethyl)-benzyl]malonic acid diethyl ester (69403-16-3)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; at 50 ℃; for 2h;

DOI:10.1016/S0040-4020(97)00989-7

upstream raw materials:

α,α'-dibromo-o-xylene

diethyl malonate

1,2-bis(iodomethyl)benzene

o-Xylylene dichloride

Downstream raw materials:

3-(2-ethylphenyl)propanoic acid

3,3'-(1,2-phenylene)dipropionic acid

o-xylylenedi-malonic acid

3-[2-(2-ethoxycarbonyl-ethyl)-phenyl]-propionic acid ethyl ester