(-)-6-(R)-<(2E)-4-<(tert-butyldimethylsilyl)oxy>3-methylbut-2-enyl>-2,5-diketo-4-(4-methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane

Base Information

Chemical Name:(-)-6-(R)-<(2E)-4-<(tert-butyldimethylsilyl)oxy>3-methylbut-2-enyl>-2,5-diketo-4-(4-methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane
CAS No.:124268-77-5
Molecular Formula:C₂₆H₄₀N₂O₄Si
Molecular Weight:472.7
Hs Code.:

Synonyms:(-)-6-(R)-<(2E)-4-<(tert-butyldimethylsilyl)oxy>3-methylbut-2-enyl>-2,5-diketo-4-(4-methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane

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Chemical Property of (-)-6-(R)-<(2E)-4-<(tert-butyldimethylsilyl)oxy>3-methylbut-2-enyl>-2,5-diketo-4-(4-methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane

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Technology Process of (-)-6-(R)-<(2E)-4-<(tert-butyldimethylsilyl)oxy>3-methylbut-2-enyl>-2,5-diketo-4-(4-methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane

There total 7 articles about (-)-6-(R)-<(2E)-4-<(tert-butyldimethylsilyl)oxy>3-methylbut-2-enyl>-2,5-diketo-4-(4-methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81286-83-1
(2R,5R)-5-allyl-2-tert-butyl-1-aza-3-oxabicyclo<3.3.0>octan-4-one

: 124268-77-5
(-)-6-(R)-<(2E)-4-<(tert-butyldimethylsilyl)oxy>3-methylbut-2-enyl>-2,5-diketo-4-(4-methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) -78 deg C, 1.5 h

2: 1.) K₂CO₃, 2.) 50percent aq. NaOH / 1.) methylene chloride, 0 deg C, 1 h, 2.) 8 h

3: 1.) ozone, 2.) dimethyl sulfide / 1.) MeOH, -78 deg C, 1 h

4: 1,2-dichloro-benzene / 3 h / 115 °C

5: 96.5 percent / NaBH₄ / ethanol / 0.33 h / 35 - 50 °C

6: triethylamine / dimethylformamide / 1 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; n-butyllithium; dimethylsulfide; potassium carbonate; ozone; triethylamine; In ethanol; N,N-dimethyl-formamide; 1,2-dichloro-benzene;

Reference yield:

: 116005-51-7
(-)-2-(R)-allyl-2-<(4-methoxybenzyl)carboxamido>pyrrolidine

: 124268-77-5
(-)-6-(R)-<(2E)-4-<(tert-butyldimethylsilyl)oxy>3-methylbut-2-enyl>-2,5-diketo-4-(4-methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) K₂CO₃, 2.) 50percent aq. NaOH / 1.) methylene chloride, 0 deg C, 1 h, 2.) 8 h

2: 1.) ozone, 2.) dimethyl sulfide / 1.) MeOH, -78 deg C, 1 h

3: 1,2-dichloro-benzene / 3 h / 115 °C

4: 96.5 percent / NaBH₄ / ethanol / 0.33 h / 35 - 50 °C

5: triethylamine / dimethylformamide / 1 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; dimethylsulfide; potassium carbonate; ozone; triethylamine; In ethanol; N,N-dimethyl-formamide; 1,2-dichloro-benzene;

Reference yield:

: 116005-52-8
(-)-2,5-diketo-6-(R)-allyl-4-(methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane

: 124268-77-5
(-)-6-(R)-<(2E)-4-<(tert-butyldimethylsilyl)oxy>3-methylbut-2-enyl>-2,5-diketo-4-(4-methoxybenzyl)-1,4-diazabicyclo<4.3.0>nonane

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) ozone, 2.) dimethyl sulfide / 1.) MeOH, -78 deg C, 1 h

2: 1,2-dichloro-benzene / 3 h / 115 °C

3: 96.5 percent / NaBH₄ / ethanol / 0.33 h / 35 - 50 °C

4: triethylamine / dimethylformamide / 1 h / Ambient temperature

With sodium tetrahydroborate; dimethylsulfide; ozone; triethylamine; In ethanol; N,N-dimethyl-formamide; 1,2-dichloro-benzene;