ethyl 2-(5,6-dihydro-2-methyl-5-tosylphenanthridin-6-yl)acetate

Base Information

• Chemical Name: ethyl 2-(5,6-dihydro-2-methyl-5-tosylphenanthridin-6-yl)acetate
• CAS No.: 1330574-17-8
• Molecular Formula: C₂₅H₂₅NO₄S
• Molecular Weight: 435.544
• Mol file: 1330574-17-8.mol

Synonyms:ethyl 2-(5,6-dihydro-2-methyl-5-tosylphenanthridin-6-yl)acetate

Chemical Property of ethyl 2-(5,6-dihydro-2-methyl-5-tosylphenanthridin-6-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of ethyl 2-(5,6-dihydro-2-methyl-5-tosylphenanthridin-6-yl)acetate

There total 6 articles about ethyl 2-(5,6-dihydro-2-methyl-5-tosylphenanthridin-6-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N-(2-bromo-4-methylphenyl)-4-methylbenzenesulfonamide (87995-68-4) + C17H23BO4 → ethyl 2-(5,6-dihydro-2-methyl-5-tosylphenanthridin-6-yl)acetate (1330574-17-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; for 4h; Schlenk technique; Inert atmosphere; Reflux;

DOI:10.1002/ejoc.201402913

Reference yield: 82.0%

→ ethyl 2-(5,6-dihydro-2-methyl-5-tosylphenanthridin-6-yl)acetate (1330574-17-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; for 6h; Reflux; Inert atmosphere;

Reference yield: 76.0%

N-Ts-4-methyl-2-phenylaniline (1312447-90-7) + ethyl acrylate (140-88-5,9003-32-1) → ethyl 2-(5,6-dihydro-2-methyl-5-tosylphenanthridin-6-yl)acetate (1330574-17-8)

Guidance literature:

With dipotassium peroxodisulfate; palladium diacetate; toluene-4-sulfonic acid; trifluoroacetic acid; In dichloromethane; at 25 ℃; for 6h; regioselective reaction;

DOI:10.1002/asia.201100024

upstream raw materials:

N-Ts-4-methyl-2-phenylaniline

ethyl acrylate

2-bromo-p-toluidine

2-amino-5-methylbiphenyl