2-(N-Benzyl-N-methylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(4-nitro-2-pyridyl)-3,5-pyridinedicarboxylate

Base Information

Chemical Name:2-(N-Benzyl-N-methylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(4-nitro-2-pyridyl)-3,5-pyridinedicarboxylate
CAS No.:108337-77-5
Molecular Formula:C₂₅H₂₈N₄O₆
Molecular Weight:480.521
Hs Code.:

Synonyms:2-(N-Benzyl-N-methylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(4-nitro-2-pyridyl)-3,5-pyridinedicarboxylate

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Chemical Property of 2-(N-Benzyl-N-methylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(4-nitro-2-pyridyl)-3,5-pyridinedicarboxylate

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Technology Process of 2-(N-Benzyl-N-methylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(4-nitro-2-pyridyl)-3,5-pyridinedicarboxylate

There total 7 articles about 2-(N-Benzyl-N-methylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(4-nitro-2-pyridyl)-3,5-pyridinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 108337-77-5
2-(N-Benzyl-N-methylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(4-nitro-2-pyridyl)-3,5-pyridinedicarboxylate

Guidance literature:

Reference yield:

: 5470-66-6
2-methyl-4-nitropyridine N-oxide

: 108337-77-5
2-(N-Benzyl-N-methylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(4-nitro-2-pyridyl)-3,5-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 18 percent / Heating

2: 74 percent / aq. NaOH / methanol / 1.5 h / Ambient temperature

3: 66 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H₃PO₄ / 1.5 h / Ambient temperature

4: propan-2-ol / 40 °C

5: dimethylformamide / 100 - 110 °C

With sodium hydroxide; phosphoric acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide; In methanol; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1248/cpb.38.2446

Reference yield:

: 931-19-1
2-methylpyridine N-oxide

: 108337-77-5
2-(N-Benzyl-N-methylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(4-nitro-2-pyridyl)-3,5-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / H₂SO₄, fuming HNO₃ / 2 h / 100 - 105 °C

2: 18 percent / Heating

3: 74 percent / aq. NaOH / methanol / 1.5 h / Ambient temperature

4: 66 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H₃PO₄ / 1.5 h / Ambient temperature

5: propan-2-ol / 40 °C

6: dimethylformamide / 100 - 110 °C

With sodium hydroxide; phosphoric acid; sulfuric acid; nitric acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide; In methanol; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1248/cpb.38.2446