methyl 1-(cyclohexylmethyl)-5-(2-hydroxyphenyl)-1H-imidazole-4-carboxylate

Base Information

• Chemical Name: methyl 1-(cyclohexylmethyl)-5-(2-hydroxyphenyl)-1H-imidazole-4-carboxylate
• CAS No.: 1309366-43-5
• Molecular Formula: C₁₈H₂₂N₂O₃
• Molecular Weight: 314.384
• Mol file: 1309366-43-5.mol

Synonyms:methyl 1-(cyclohexylmethyl)-5-(2-hydroxyphenyl)-1H-imidazole-4-carboxylate

Chemical Property of methyl 1-(cyclohexylmethyl)-5-(2-hydroxyphenyl)-1H-imidazole-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of methyl 1-(cyclohexylmethyl)-5-(2-hydroxyphenyl)-1H-imidazole-4-carboxylate

There total 1 articles about methyl 1-(cyclohexylmethyl)-5-(2-hydroxyphenyl)-1H-imidazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

Ethyl isocyanoacetate (2999-46-4) + salicylaldehyde (90-02-8) + cyclohexylmethylamine (3218-02-8) → methyl 1-(cyclohexylmethyl)-5-(2-hydroxyphenyl)-1H-imidazole-4-carboxylate (1309366-43-5)

Guidance literature:

With pyridine; copper(l) iodide; In methanol; at 50 ℃;

DOI:10.1002/adsc.201000895

Reference yield: 85.0%

methyl 1-(cyclohexylmethyl)-5-(2-hydroxyphenyl)-1H-imidazole-4-carboxylate (1309366-43-5) → 1-(cyclohexylmethyl)chromeno[3,4-d]imidazol-4(1H)-one (950271-99-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 180 ℃; for 0.166667h; Microwave irradiation;

DOI:10.1002/adsc.201000895

upstream raw materials:

Ethyl isocyanoacetate

salicylaldehyde

cyclohexylmethylamine

Downstream raw materials:

1-(cyclohexylmethyl)chromeno[3,4-d]imidazol-4(1H)-one