ethyl 5-[(4-anilino-3,5-dicyanopyridin-2-yl)oxy]-1-(4-methoxyphenyl)-2-methyl-1H-indole-3-carboxylate

Base Information

Chemical Name:ethyl 5-[(4-anilino-3,5-dicyanopyridin-2-yl)oxy]-1-(4-methoxyphenyl)-2-methyl-1H-indole-3-carboxylate
CAS No.:134826-58-7
Molecular Formula:C₃₂H₂₅N₅O₄
Molecular Weight:543.582
Hs Code.:
Mol file:134826-58-7.mol

Synonyms:5-(3,5-Dicyano-4-phenylamino-pyridin-2-yloxy)-1-(4-methoxy-phenyl)-2-methyl-1H-indole-3-carboxylic acid ethyl ester

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Chemical Property of ethyl 5-[(4-anilino-3,5-dicyanopyridin-2-yl)oxy]-1-(4-methoxyphenyl)-2-methyl-1H-indole-3-carboxylate

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Technology Process of ethyl 5-[(4-anilino-3,5-dicyanopyridin-2-yl)oxy]-1-(4-methoxyphenyl)-2-methyl-1H-indole-3-carboxylate

There total 1 articles about ethyl 5-[(4-anilino-3,5-dicyanopyridin-2-yl)oxy]-1-(4-methoxyphenyl)-2-methyl-1H-indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.3%

: 134826-46-3
2-chloro-3,5-dicyano-4-phenylaminopyridine

: 5165-50-4
ethyl 5-hydroxy-1-(4-methoxyphenyl)-2-methyl-1H-indole-3-carboxylate

: 134826-58-7
5-(3,5-Dicyano-4-phenylamino-pyridin-2-yloxy)-1-(4-methoxy-phenyl)-2-methyl-1H-indole-3-carboxylic acid ethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 5h; Heating;
DOI:10.1007/BF00772102

Reference yield: 94.3%

: 134826-58-7
5-(3,5-Dicyano-4-phenylamino-pyridin-2-yloxy)-1-(4-methoxy-phenyl)-2-methyl-1H-indole-3-carboxylic acid ethyl ester

: 136038-24-9
2-Chloromethyl-5-(3,5-dicyano-4-phenylamino-pyridin-2-yloxy)-1-(4-methoxy-phenyl)-1H-indole-3-carboxylic acid ethyl ester

Guidance literature:: With sulfuryl dichloride; In chloroform; for 0.5h; Ambient temperature;
DOI:10.1007/BF00772140

Reference yield:

: 134826-58-7
5-(3,5-Dicyano-4-phenylamino-pyridin-2-yloxy)-1-(4-methoxy-phenyl)-2-methyl-1H-indole-3-carboxylic acid ethyl ester

: 136038-42-1
5-(3,5-Dicyano-4-phenylamino-pyridin-2-yloxy)-2-diethylaminomethyl-1-(4-methoxy-phenyl)-1H-indole-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94.3 percent / SO₂Cl₂ / CHCl₃ / 0.5 h / Ambient temperature

2: 68.7 percent / benzene / Heating

With sulfuryl dichloride; In chloroform; benzene;
DOI:10.1007/BF00772140