Pyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-trione, 7-[(dimethylamino)methylene]-6,7-dihydro-6-hydroxy-1,3-dimethyl-9-(phenylmethyl)- (9CI)

Base Information

Chemical Name:Pyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-trione, 7-[(dimethylamino)methylene]-6,7-dihydro-6-hydroxy-1,3-dimethyl-9-(phenylmethyl)- (9CI)
CAS No.:102212-90-8
Molecular Formula:C20H22 N6 O4
Molecular Weight:0
Hs Code.:
Mol file:102212-90-8.mol

Synonyms:Pyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-trione,7-[(dimethylamino)methylene]-6,7-dihydro-6-hydroxy-1,3-dimethyl-9-(phenylmethyl)-(9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-trione, 7-[(dimethylamino)methylene]-6,7-dihydro-6-hydroxy-1,3-dimethyl-9-(phenylmethyl)- (9CI)

Chemical Property:

PSA：105.60000
LogP:-0.01810

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Pyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-trione, 7-[(dimethylamino)methylene]-6,7-dihydro-6-hydroxy-1,3-dimethyl-9-(phenylmethyl)- (9CI)

There total 3 articles about Pyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-trione, 7-[(dimethylamino)methylene]-6,7-dihydro-6-hydroxy-1,3-dimethyl-9-(phenylmethyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 91285-01-7
9-benzyl-1,3-dimethyl-6-(hydroxy)pyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-trione

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 102212-90-8
9-benzyl-1,3-dimethyl-7-<(N,N-dimethylamino)methenyl>-6-hydroxypyrimido<2,1-f>purine-2,48(1H,3H,9H)-trione

Guidance literature:: With trichlorophosphate; for 22h;
DOI:10.1021/jm00156a032

Reference yield:

: 57000-13-2
8-(benzylamino)-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione

: 102212-90-8
9-benzyl-1,3-dimethyl-7-<(N,N-dimethylamino)methenyl>-6-hydroxypyrimido<2,1-f>purine-2,48(1H,3H,9H)-trione

Guidance literature:: Multi-step reaction with 2 steps

1: NaOMe / 9 h / 200 - 210 °C

2: 91 percent / POCl₃ / 22 h

With sodium methylate; trichlorophosphate;
DOI:10.1021/jm00156a032

Reference yield:

: 100-46-9
benzylamine

: 102212-90-8
9-benzyl-1,3-dimethyl-7-<(N,N-dimethylamino)methenyl>-6-hydroxypyrimido<2,1-f>purine-2,48(1H,3H,9H)-trione

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / 4 h / Heating

2: NaOMe / 9 h / 200 - 210 °C

3: 91 percent / POCl₃ / 22 h

With sodium methylate; trichlorophosphate;
DOI:10.1021/jm00156a032