4-(benzyloxymethyl)-6-bromo-2-(2-oxo-2-phenylethyl)-1,2,4-triazine-3,5(2H,4H)-dione

Base Information

Chemical Name:4-(benzyloxymethyl)-6-bromo-2-(2-oxo-2-phenylethyl)-1,2,4-triazine-3,5(2H,4H)-dione
CAS No.:1562528-47-5
Molecular Formula:C₁₉H₁₆BrN₃O₄
Molecular Weight:430.258
Hs Code.:

Synonyms:4-(benzyloxymethyl)-6-bromo-2-(2-oxo-2-phenylethyl)-1,2,4-triazine-3,5(2H,4H)-dione

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Chemical Property of 4-(benzyloxymethyl)-6-bromo-2-(2-oxo-2-phenylethyl)-1,2,4-triazine-3,5(2H,4H)-dione

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Technology Process of 4-(benzyloxymethyl)-6-bromo-2-(2-oxo-2-phenylethyl)-1,2,4-triazine-3,5(2H,4H)-dione

There total 1 articles about 4-(benzyloxymethyl)-6-bromo-2-(2-oxo-2-phenylethyl)-1,2,4-triazine-3,5(2H,4H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1206515-76-5
4-(benzyloxymethyl)-6-bromo-1,2,4-triazine-3,5(2H,4H)-dione

: 70-11-1
α-bromoacetophenone

: 1562528-47-5
4-(benzyloxymethyl)-6-bromo-2-(2-oxo-2-phenylethyl)-1,2,4-triazine-3,5(2H,4H)-dione

Guidance literature:: 4-(benzyloxymethyl)-6-bromo-1,2,4-triazine-3,5(2H,4H)-dione; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

α-bromoacetophenone; In N,N-dimethyl-formamide; for 3.5h;

Reference yield:

: 1562528-47-5
4-(benzyloxymethyl)-6-bromo-2-(2-oxo-2-phenylethyl)-1,2,4-triazine-3,5(2H,4H)-dione

: 100-51-6,185532-71-2
benzyl alcohol

: 1562528-48-6
6-(benzyloxy)-4-(benzyloxymethyl)-2-(2-oxo-2-phenylethyl)-1,2,4-triazine-3,5(2H,4H)-dione

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃;
DOI:10.1021/acs.jmedchem.5b00482

Reference yield:

: 1562528-47-5
4-(benzyloxymethyl)-6-bromo-2-(2-oxo-2-phenylethyl)-1,2,4-triazine-3,5(2H,4H)-dione

: C₂₆H₂₅N₃O₅

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 0 °C

2: hydrogen; chloro(1,5-cyclooctadiene)rhodium(I) dimer; triethylamine / methanol; ethyl acetate

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; hydrogen; sodium hydride; triethylamine; In methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.5b00482