N₁-(3-(4-{[4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}benzamido)-2,2-dimethylpropyl)-N₂,N₂-dimethyloxalamide

Base Information

• Chemical Name: N₁-(3-(4-{[4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}benzamido)-2,2-dimethylpropyl)-N₂,N₂-dimethyloxalamide
• CAS No.: 1449396-70-6
• Molecular Formula: C₃₀H₃₄ClF₃N₈O₄
• Molecular Weight: 663.099

Synonyms:N₁-(3-(4-{[4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}benzamido)-2,2-dimethylpropyl)-N₂,N₂-dimethyloxalamide

Chemical Property of N₁-(3-(4-{[4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}benzamido)-2,2-dimethylpropyl)-N₂,N₂-dimethyloxalamide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N₁-(3-(4-{[4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}benzamido)-2,2-dimethylpropyl)-N₂,N₂-dimethyloxalamide

There total 7 articles about N₁-(3-(4-{[4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}benzamido)-2,2-dimethylpropyl)-N₂,N₂-dimethyloxalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-dimethyloxamic acid (32833-96-8) + N-(3-amino-2,2-dimethylpropyl)-4-{[4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}benzamide (1449410-38-1) → N1-(3-(4-{[4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}benzamido)-2,2-dimethylpropyl)-N2,N2-dimethyloxalamide (1449396-70-6)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

Reference yield:

tert-butyl 4-((4-((1-(4-chlorophenyl)cyclopropyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)benzoate (1360828-40-5) → N1-(3-(4-{[4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}benzamido)-2,2-dimethylpropyl)-N2,N2-dimethyloxalamide (1449396-70-6)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / 1,4-dioxane / 4 h

2: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 16 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 6 h / 20 °C

With hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

2,4-dichloro-6-(2,2,2-trifluoroethoxy)-1,3,5-triazine (185677-00-3) → N1-(3-(4-{[4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}benzamido)-2,2-dimethylpropyl)-N2,N2-dimethyloxalamide (1449396-70-6)

Guidance literature:

Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h

2: tetrahydrofuran / 5 h / 80 °C

3: hydrogenchloride / 1,4-dioxane / 4 h

4: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 16 h / 20 °C

5: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

6: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 6 h / 20 °C

With hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyl 4-((4-((1-(4-chlorophenyl)cyclopropyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)benzoate

2,4-dichloro-6-(2,2,2-trifluoroethoxy)-1,3,5-triazine

tert-butyl 3-(4-{[4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}benzamido)-2,2-dimethylpropylcarbamate

N,N-dimethyloxamic acid

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