2-chloro-4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]pyridine

Base Information

Chemical Name:2-chloro-4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]pyridine
CAS No.:1445890-02-7
Molecular Formula:C₂₂H₂₄Cl₂N₆OSi
Molecular Weight:487.464
Hs Code.:

Synonyms:2-chloro-4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]pyridine

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Chemical Property of 2-chloro-4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]pyridine

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Technology Process of 2-chloro-4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]pyridine

There total 7 articles about 2-chloro-4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445890-00-5
2-chloro-4-[3-(2-chlorophenyl)-4-(1H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]pyridine

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1445890-02-7
2-chloro-4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]pyridine

: 2-chloro-4-[3-(2-chlorophenyl)-4-(4-{[2-(trimethylsilyl)ethoxy]methyl}-4H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]pyridine

Guidance literature:: 2-chloro-4-[3-(2-chlorophenyl)-4-(1H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]pyridine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 0.166667h; Inert atmosphere;

(2-trimethylethylsilylethoxy)methyl chloride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 1.5h; Overall yield = 1.67 g;

Reference yield:

: 1445889-94-0
methyl 3-(2-chlorophenyl)-1-(2-chloropyridin-4-yl)-1H-pyrazole-4-carboxylate

: 1445890-02-7
2-chloro-4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]pyridine

: 2-chloro-4-[3-(2-chlorophenyl)-4-(4-{[2-(trimethylsilyl)ethoxy]methyl}-4H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / tetrahydrofuran / 80 °C

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 0.25 h / 20 °C

2.2: 20 °C

3.1: toluene / 2 h / 50 °C

3.2: 3 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 - 20 °C / Inert atmosphere

4.2: 1.5 h / 0 °C

With water; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1445889-96-2
3-(2-chlorophenyl)-1-(2-chloropyridin-4-yl)-1H-pyrazole-4-carboxylic acid

: 1445890-02-7
2-chloro-4-[3-(2-chlorophenyl)-4-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]pyridine

: 2-chloro-4-[3-(2-chlorophenyl)-4-(4-{[2-(trimethylsilyl)ethoxy]methyl}-4H-1,2,4-triazol-3-yl)-1H-pyrazol-1-yl]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 0.25 h / 20 °C

1.2: 20 °C

2.1: toluene / 2 h / 50 °C

2.2: 3 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 - 20 °C / Inert atmosphere

3.2: 1.5 h / 0 °C

With sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;