(Z)-3-(3-(4-chloro-3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

Base Information

Chemical Name:(Z)-3-(3-(4-chloro-3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid
CAS No.:1421923-99-0
Molecular Formula:C₁₃H₆ClF₆N₃O₂
Molecular Weight:385.653
Hs Code.:

Synonyms:(Z)-3-(3-(4-chloro-3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

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Chemical Property of (Z)-3-(3-(4-chloro-3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

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Technology Process of (Z)-3-(3-(4-chloro-3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

There total 5 articles about (Z)-3-(3-(4-chloro-3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421923-98-9
(Z)-isopropyl 3-(3-(4-chloro-3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

: 1421923-99-0
(Z)-3-(3-(4-chloro-3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 4h;

Reference yield:

: 62584-30-9
4-chloro-3,5-bis(trifluoromethyl)benzonitrile

: 1421923-99-0
(Z)-3-(3-(4-chloro-3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide / 3 h / 20 °C

2.1: Lawessons reagent / toluene / 8 h / 90 °C

3.1: hydrazine hydrate / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 3 h / 90 °C

4.1: 1,4-diaza-bicyclo[2.2.2]octane / N,N-dimethyl-formamide / 0.5 h

4.2: 5 h / 20 °C

5.1: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C

With Lawessons reagent; 1,4-diaza-bicyclo[2.2.2]octane; water; dihydrogen peroxide; potassium carbonate; hydrazine hydrate; lithium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1421920-52-6
4-chloro-3,5-bis(trifluoromethyl)benzamide

: 1421923-99-0
(Z)-3-(3-(4-chloro-3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: Lawessons reagent / toluene / 8 h / 90 °C

2.1: hydrazine hydrate / N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 3 h / 90 °C

3.1: 1,4-diaza-bicyclo[2.2.2]octane / N,N-dimethyl-formamide / 0.5 h

3.2: 5 h / 20 °C

4.1: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C

With Lawessons reagent; 1,4-diaza-bicyclo[2.2.2]octane; water; hydrazine hydrate; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;