N-ISOPROPYL-4-PIPERIDINECARBOXAMIDE HYDROCHLORIDE

Base Information

• Chemical Name: N-ISOPROPYL-4-PIPERIDINECARBOXAMIDE HYDROCHLORIDE
• CAS No.: 102125-62-2
• Molecular Formula: C₉H₁₈N₂O
• Molecular Weight: 170.255
• Hs Code.: 2933399090
• Mol file: 102125-62-2.mol

Synonyms:N-ISOPROPYL-4-PIPERIDINECARBOXAMIDE HYDROCHLORIDE

Chemical Property of N-ISOPROPYL-4-PIPERIDINECARBOXAMIDE HYDROCHLORIDE

Chemical Property:

• PSA: 41.13000
• LogP: 1.23030

Purity/Quality:

97% ^*data from raw suppliers

N-Isopropylpiperidine-4-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-ISOPROPYL-4-PIPERIDINECARBOXAMIDE HYDROCHLORIDE

There total 5 articles about N-ISOPROPYL-4-PIPERIDINECARBOXAMIDE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

tert-butyl 4-(isopropylcarbamoyl)piperidine-1-carboxylate (1016716-09-8) → N-isopropylpiperidine-4-carboxamide (102125-62-2)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.ejmech.2014.12.018

Reference yield:

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid (84358-13-4,174286-31-8) → N-isopropylpiperidine-4-carboxamide (102125-62-2)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine; thionyl chloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2: triethylamine; dmap / dichloromethane / 20 °C / Inert atmosphere

3: trifluoroacetic acid / 24 h / 20 °C / Inert atmosphere

With pyridine; dmap; thionyl chloride; triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.ejmech.2014.12.018

Reference yield:

isonipecotic acid (498-94-2) → N-isopropylpiperidine-4-carboxamide (102125-62-2)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / tetrahydrofuran; water / 4 h / 20 °C

2: pyridine; thionyl chloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3: triethylamine; dmap / dichloromethane / 20 °C / Inert atmosphere

4: trifluoroacetic acid / 24 h / 20 °C / Inert atmosphere

With pyridine; dmap; thionyl chloride; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;

DOI:10.1016/j.ejmech.2014.12.018

upstream raw materials:

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

isonipecotic acid

tert-butyl 4-(chlorocarbonyl)-piperidine-1-carboxylate

tert-butyl 4-(isopropylcarbamoyl)piperidine-1-carboxylate