7-Chloro-5-(2-fluoro-phenyl)-1-(1-methyl-pyrrolidin-3-yl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

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Chemical Name:7-Chloro-5-(2-fluoro-phenyl)-1-(1-methyl-pyrrolidin-3-yl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one
CAS No.:96110-69-9
Molecular Formula:C₂₀H₁₉ClFN₃O
Molecular Weight:371.842
Hs Code.:

Synonyms:7-Chloro-5-(2-fluoro-phenyl)-1-(1-methyl-pyrrolidin-3-yl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

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Chemical Property of 7-Chloro-5-(2-fluoro-phenyl)-1-(1-methyl-pyrrolidin-3-yl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 7-Chloro-5-(2-fluoro-phenyl)-1-(1-methyl-pyrrolidin-3-yl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

There total 5 articles about 7-Chloro-5-(2-fluoro-phenyl)-1-(1-methyl-pyrrolidin-3-yl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 96110-97-3
7-Chloro-5-(2-fluoro-phenyl)-1-pyrrolidin-3-yl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

: 96110-69-9
7-Chloro-5-(2-fluoro-phenyl)-1-(1-methyl-pyrrolidin-3-yl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Guidance literature:: With hydrogen; nickel; In methanol; ethanol; water; for 2h; Ambient temperature;
DOI:10.1021/jm00383a003

Reference yield:

: 96524-59-3
(1-Benzyl-pyrrolidin-3-yl)-{4-chloro-2-[(2-fluoro-phenyl)-imino-methyl]-phenyl}-amine

: 96110-69-9
7-Chloro-5-(2-fluoro-phenyl)-1-(1-methyl-pyrrolidin-3-yl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: AcOH / ethanol / 3 h / Heating

2: TFA / 20 h / Heating

3: CH₂Cl₂ / 0.5 h / Heating

4: methanesulfonic acid, tetrahydrothiophene / 0.5 h / 120 °C

5: 42 percent / H₂ / Raney Ni / H₂O; ethanol; methanol / 2 h / Ambient temperature

With thiophene; methanesulfonic acid; hydrogen; acetic acid; trifluoroacetic acid; nickel; In methanol; ethanol; dichloromethane; water;
DOI:10.1021/jm00383a003

Reference yield:

: 3-[7-Chloro-5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-pyrrolidine-1-carboxylic acid ethyl ester

: 96110-69-9
7-Chloro-5-(2-fluoro-phenyl)-1-(1-methyl-pyrrolidin-3-yl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: methanesulfonic acid, tetrahydrothiophene / 0.5 h / 120 °C

2: 42 percent / H₂ / Raney Ni / H₂O; ethanol; methanol / 2 h / Ambient temperature

With thiophene; methanesulfonic acid; hydrogen; nickel; In methanol; ethanol; water;
DOI:10.1021/jm00383a003