N-benzyloxycarbonyl-(2S)-aminobutyryl-(2S)-indolinecarboxylic acid methylamide

Base Information

Chemical Name:N-benzyloxycarbonyl-(2S)-aminobutyryl-(2S)-indolinecarboxylic acid methylamide
CAS No.:185213-10-9
Molecular Formula:C₂₂H₂₅N₃O₄
Molecular Weight:395.458
Hs Code.:

Synonyms:N-benzyloxycarbonyl-(2S)-aminobutyryl-(2S)-indolinecarboxylic acid methylamide

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Chemical Property of N-benzyloxycarbonyl-(2S)-aminobutyryl-(2S)-indolinecarboxylic acid methylamide

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Technology Process of N-benzyloxycarbonyl-(2S)-aminobutyryl-(2S)-indolinecarboxylic acid methylamide

There total 3 articles about N-benzyloxycarbonyl-(2S)-aminobutyryl-(2S)-indolinecarboxylic acid methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 185213-08-5
N-benzyloxycarbonyl-(2S)-indolinecarboxylic acid methylamide

: 185213-10-9
N-benzyloxycarbonyl-(2S)-aminobutyryl-(2S)-indolinecarboxylic acid methylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 91 percent / H₂ / Pd/C / methanol / 3 h / 25 °C / 1551.44 Torr

2.1: isobutyl chloroformate; N-ethylmorpholine / tetrahydrofuran / 0.5 h

2.2: 64 percent / tetrahydrofuran / 20 °C

With N-ethylmorpholine;; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm0500830

Reference yield:

: 104261-79-2
(S)-1-(benzyloxycarbonyl)indoline-2-carboxylic acid

: 185213-10-9
N-benzyloxycarbonyl-(2S)-aminobutyryl-(2S)-indolinecarboxylic acid methylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: isobutyl chloroformate; N-ethylmorpholine / tetrahydrofuran / 0.5 h

1.2: 70.5 percent / tetrahydrofuran / 20 °C

2.1: 91 percent / H₂ / Pd/C / methanol / 3 h / 25 °C / 1551.44 Torr

3.1: isobutyl chloroformate; N-ethylmorpholine / tetrahydrofuran / 0.5 h

3.2: 64 percent / tetrahydrofuran / 20 °C

With N-ethylmorpholine;; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm0500830