5-Aminophthalazine

Base Information

Chemical Name:5-Aminophthalazine
CAS No.:102072-84-4
Molecular Formula:C₈H₇N₃
Molecular Weight:145.164
Hs Code.:2933990090
European Community (EC) Number:821-146-9
DSSTox Substance ID:DTXSID90459346
Wikidata:Q82283096
ChEMBL ID:CHEMBL246237
Mol file:102072-84-4.mol

Synonyms:5-aminophthalazine

Suppliers and Price of 5-Aminophthalazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-Aminophthalazine
500mg
$ 290.00

SynQuest Laboratories
5-Aminophthalazine 95%
1 g
$ 504.00

SynChem
5-Aminophthalazine 95+%
1 g
$ 200.00

SynChem
5-Aminophthalazine 95+%
5 g
$ 620.00

Matrix Scientific
5-Aminophthalazine 95+%
5g
$ 685.00

Matrix Scientific
5-Aminophthalazine 95+%
1g
$ 260.00

Matrix Scientific
5-Aminophthalazine 95+%
500mg
$ 170.00

Crysdot
5-Aminophthalazine 98%
1g
$ 131.00

Crysdot
5-Aminophthalazine 98%
250mg
$ 64.00

Crysdot
5-Aminophthalazine 98%
5g
$ 381.00

Total 35 raw suppliers

Chemical Property of 5-Aminophthalazine

Chemical Property:

Vapor Pressure:2.28E-07mmHg at 25°C
Melting Point:223-224 °C(Solv: methanol (67-56-1))
Refractive Index:1.723
Boiling Point:423.2 °C at 760 mmHg
PKA:5.32±0.30(Predicted)
Flash Point:239.3 °C
PSA：51.80000
Density:1.292 g/cm³
LogP:1.79320
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature
XLogP3:0.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:145.063997236
Heavy Atom Count:11
Complexity:137

Purity/Quality:

98% ^*data from raw suppliers

5-Aminophthalazine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=CN=NC=C2C(=C1)N
Uses 5-Aminophthalazine is a building block that was used as a reactant in the synthetic preparation of ezrin inhibitors targeting metastatic osteosarcoma.

Technology Process of 5-Aminophthalazine

There total 4 articles about 5-Aminophthalazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 89898-86-2
5-nitrophthalazine

: 102072-84-4
5-aminophthalazine

Guidance literature:: With sodium dithionite; In tetrahydrofuran; methanol; water; for 0.0833333h; Heating;
DOI:10.1021/jm00158a002

Reference yield:

: 253-52-1
PHTHALAZINE

: 102072-84-4
5-aminophthalazine

Guidance literature:: Multi-step reaction with 2 steps

1: H₂SO₄; KNO₃ / 16 h / 70 - 80 °C

2: H₂ / Pd/C / ethanol / 23 h / 760 Torr

With sulfuric acid; hydrogen; potassium nitrate; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm0492958

Reference yield:

: 484-23-1
1,4-bis(hydrazino)phthalazine

: 102072-84-4
5-aminophthalazine

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / NaOH, O₂ / ethanol / 2.5 h

2: 17 percent / KNO₃, concd H₂SO₄ / 12 h / 100 °C

3: 73 percent / sodium dithionite / methanol; tetrahydrofuran; H₂O / 0.08 h / Heating

With sodium hydroxide; sodium dithionite; sulfuric acid; oxygen; potassium nitrate; In tetrahydrofuran; methanol; ethanol; water;
DOI:10.1021/jm00158a002