(S)-(-)-1-(2-METHOXYBENZOYL)-2-PYRROLIDINEMETHANOL

Base Information

• Chemical Name: (S)-(-)-1-(2-METHOXYBENZOYL)-2-PYRROLIDINEMETHANOL
• CAS No.: 102069-83-0
• Molecular Formula: C13H17 N O3
• Molecular Weight: 235.283
• Hs Code.: 2933990090
• Mol file: 102069-83-0.mol

Synonyms:2-Pyrrolidinemethanol,1-(2-methoxybenzoyl)-, (2S)- (9CI);2-Pyrrolidinemethanol, 1-(2-methoxybenzoyl)-,(S)-;(-)-1-(2-Methoxybenzoyl)-2-pyrrolidine methanol;(2S)-1-(2-Methoxybenzoyl)-2-pyrrolidinemethanol;(S)-(-)-1-(2-Methoxybenzoyl)-2-pyrrolidinemethanol;

Chemical Property of (S)-(-)-1-(2-METHOXYBENZOYL)-2-PYRROLIDINEMETHANOL

Chemical Property:

• Vapor Pressure: 5.55E-08mmHg at 25°C
• Melting Point: 104-107 °C(lit.)
• Refractive Index: 1.561
• Boiling Point: 425°Cat760mmHg
• Flash Point: 210.9°C
• PSA: 49.77000
• Density: 1.18g/cm³
• LogP: 1.23000

Purity/Quality:

99%min ^*data from raw suppliers

(S)-(-)-1-(2-METHOXYBENZOYL)-2-PYRROLIDINE METHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-(-)-1-(2-METHOXYBENZOYL)-2-PYRROLIDINEMETHANOL

There total 2 articles about (S)-(-)-1-(2-METHOXYBENZOYL)-2-PYRROLIDINEMETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

D-prolinol (68832-13-3) + 2-Methoxybenzoyl chloride (21615-34-9) → 2-methoxy-1-<<2(S)-(hydroxymethyl)pyrrolidinyl>carbonyl>benzene (102069-83-0,207511-15-7)

Guidance literature:

With triethylamine; In dichloromethane; 1.) 0 deg C, 1 h 2.) rt, 24 h;

DOI:10.1021/ja00247a027

Reference yield:

2-Methoxybenzoyl chloride (21615-34-9) + (S)-1-Pyrrolidin-2-yl-methanol (23356-96-9) → 2-methoxy-1-<<2(S)-(hydroxymethyl)pyrrolidinyl>carbonyl>benzene (102069-83-0,207511-15-7)

Guidance literature:

DOI:10.1016/S0040-4039(00)98755-0

Reference yield: 88.0%

2-methoxy-1-<<2(S)-(hydroxymethyl)pyrrolidinyl>carbonyl>benzene (102069-83-0,207511-15-7) → (S)-(2-(fluoromethyl)pyrrolidin-1-yl)(2-methoxyphenyl)methanone (1082738-95-1)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at 60 ℃; for 0.5h; chemoselective reaction;

DOI:10.1055/s-2008-1078026

upstream raw materials:

D-prolinol

2-Methoxybenzoyl chloride

(S)-1-Pyrrolidin-2-yl-methanol

Downstream raw materials:

(S)-1-(2-Methoxy-benzoyl)-pyrrolidine-2-carbaldehyde

2-methoxy-1-<<2(S)-<(methoxymethoxy)methyl>pyrrolidinyl>carbonyl>benzene

(S)-2-methoxy-1-[[2'-(methoxymethyl)pyrrolidinyl]carbonyl]benzene

((S)-2-Hydroxymethyl-pyrrolidin-1-yl)-((R)-2-methoxy-1-methyl-cyclohexa-2,5-dienyl)-methanone