3-[5-(methoxycarbonyl)-3,4-dihydro-2,7-naphthyridin-2(1H)-yl]benzoic acid

Base Information

Chemical Name:3-[5-(methoxycarbonyl)-3,4-dihydro-2,7-naphthyridin-2(1H)-yl]benzoic acid
CAS No.:1454657-68-1
Molecular Formula:C₁₇H₁₆N₂O₄
Molecular Weight:312.325
Hs Code.:

Synonyms:3-[5-(methoxycarbonyl)-3,4-dihydro-2,7-naphthyridin-2(1H)-yl]benzoic acid

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Chemical Property of 3-[5-(methoxycarbonyl)-3,4-dihydro-2,7-naphthyridin-2(1H)-yl]benzoic acid

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Technology Process of 3-[5-(methoxycarbonyl)-3,4-dihydro-2,7-naphthyridin-2(1H)-yl]benzoic acid

There total 11 articles about 3-[5-(methoxycarbonyl)-3,4-dihydro-2,7-naphthyridin-2(1H)-yl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1454657-67-0
7-(3-tert-butoxycarbonyl-phenyl)-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carboxylic acid methyl ester

: 1454657-68-1
3-[5-(methoxycarbonyl)-3,4-dihydro-2,7-naphthyridin-2(1H)-yl]benzoic acid

Guidance literature:: With formic acid; at 30 - 50 ℃;

Reference yield:

: 41276-30-6
C₉H₁₄O₃NC₆H₅

: 1454657-68-1
3-[5-(methoxycarbonyl)-3,4-dihydro-2,7-naphthyridin-2(1H)-yl]benzoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: potassium hydroxide / methanol / 4 h / Reflux

2: trichlorophosphate / 4 h / 180 °C / Sealed tube

3: triethylamine; hydrogen; palladium 10% on activated carbon / methanol / 3 h

4: water; sodium hydroxide / ethanol / 8 h / Reflux

5: sulfuric acid / 24 h / Reflux

6: palladium 10% on activated carbon; ammonium formate / methanol

7: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; caesium carbonate / toluene / 100 °C / Inert atmosphere; Sealed tube

8: formic acid / 30 - 50 °C

With formic acid; sulfuric acid; palladium 10% on activated carbon; water; hydrogen; ammonium formate; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; potassium hydroxide; sodium hydroxide; trichlorophosphate; In methanol; ethanol; toluene;

Reference yield:

: 1454657-66-9
5,6,7,8-tetrahydro-[2,7]naphthyridine-4-carboxylic acid methyl ester

: 1454657-68-1
3-[5-(methoxycarbonyl)-3,4-dihydro-2,7-naphthyridin-2(1H)-yl]benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; caesium carbonate / toluene / 100 °C / Inert atmosphere; Sealed tube

2: formic acid / 30 - 50 °C

With formic acid; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene;