4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-methylcyclohexanecarboxylic acid

Base Information

Chemical Name:4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-methylcyclohexanecarboxylic acid
CAS No.:1310478-83-1
Molecular Formula:C₁₆H₁₇NO₄
Molecular Weight:287.315
Hs Code.:

Synonyms:4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-methylcyclohexanecarboxylic acid

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Chemical Property of 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-methylcyclohexanecarboxylic acid

Chemical Property:

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Technology Process of 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-methylcyclohexanecarboxylic acid

There total 1 articles about 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-methylcyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1310478-81-9
ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-methylcyclohexanecarboxylate

: 1310478-83-1
4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-methylcyclohexanecarboxylic acid

Guidance literature:: ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-methylcyclohexanecarboxylate; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

With water; sodium hydroxide; In tetrahydrofuran; methanol; at 60 ℃; for 8h;

Reference yield:

: 1310478-83-1
4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-methylcyclohexanecarboxylic acid

: 2106-02-7
2-chloro-4-fluoroaniline

: N-(2-chloro-4-fluorophenyl)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-methylcyclohexanecarboxamide

Guidance literature:: 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-methylcyclohexanecarboxylic acid; With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In dichloromethane; for 1h;

2-chloro-4-fluoroaniline; In dichloromethane; at 20 - 40 ℃; for 20h;

Reference yield:

: 1310478-83-1
4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-methylcyclohexanecarboxylic acid

: 4-amino-N-(2-chloro-4-fluorophenyl)-1-methylcyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 1 h

1.2: 20 h / 20 - 40 °C

2.1: hydrazine hydrate / ethanol / 3 h / 80 °C

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; hydrazine hydrate; In ethanol; dichloromethane;