ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-methylcyclohexanecarboxylate

Base Information

Chemical Name:ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-methylcyclohexanecarboxylate
CAS No.:1310478-81-9
Molecular Formula:C₁₈H₂₁NO₄
Molecular Weight:315.369
Hs Code.:

Synonyms:ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-methylcyclohexanecarboxylate

Suppliers and Price of ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-methylcyclohexanecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-methylcyclohexanecarboxylate

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-methylcyclohexanecarboxylate

There total 7 articles about ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-methylcyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 709638-18-6
ethyl 4-(1,3-dioxoisoindolin-2-yl)cyclohexanecarboxylate

: 74-88-4
methyl iodide

: 1310478-81-9
ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-methylcyclohexanecarboxylate

Guidance literature:: ethyl 4-(1,3-dioxoisoindolin-2-yl)cyclohexanecarboxylate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; at -78 - 20 ℃;

Reference yield:

: ethyl (1r,4r)-4-(1,3-dicarbonylisoindolin-2-yl)cyclohexane-1-carboxylate

: 74-88-4
methyl iodide

: 1310478-81-9
ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-methylcyclohexanecarboxylate

Guidance literature:: ethyl (1r,4r)-4-(1,3-dicarbonylisoindolin-2-yl)cyclohexane-1-carboxylate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield:

: 1776-53-0
4-aminocyclohexanecarboxylic acid

: 1310478-81-9
ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-methylcyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / ethanol / 3 h / 80 °C / Cooling with ice

2.1: triethylamine / toluene / 8 h / Reflux; Dean-Stark

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

3.2: -78 - 20 °C

With thionyl chloride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; ethanol; toluene;