(1R,2S,3S,5S)-3-(4-Vinyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester

Base Information

• Chemical Name: (1R,2S,3S,5S)-3-(4-Vinyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester
• CAS No.: 1027023-79-5
• Molecular Formula: C₂₀H₂₂Cl₃NO₄
• Molecular Weight: 446.758
• Mol file: 1027023-79-5.mol

Synonyms:(1R,2S,3S,5S)-3-(4-Vinyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester

Chemical Property of (1R,2S,3S,5S)-3-(4-Vinyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S,3S,5S)-3-(4-Vinyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester

There total 1 articles about (1R,2S,3S,5S)-3-(4-Vinyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

vinyl zinc chloride (78389-90-9) + (1R,2S,3S,5S)-3-(4-Iodo-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester (156496-01-4) → (1R,2S,3S,5S)-3-(4-Vinyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester (1027023-79-5)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran;

DOI:10.1021/jm970492z

Reference yield: 84.0%

(1R,2S,3S,5S)-3-(4-Vinyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester (1027023-79-5) → (1R,2S,3S,5S)-3-(4-Ethyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester (1026460-96-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/jm970492z

Reference yield:

(1R,2S,3S,5S)-3-(4-Vinyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester (1027023-79-5) → (1R,2S,3S,5S)-3-(4-Ethyl-3-iodo-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester (1026290-19-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / H₂ / Pd/C / methanol

2: 68 percent / I₂, AcOH, HClO₄, HgO

With perchloric acid; hydrogen; iodine; acetic acid; mercury(II) oxide; palladium on activated charcoal; In methanol;

DOI:10.1021/jm970492z

upstream raw materials:

vinyl zinc chloride

(1R,2S,3S,5S)-3-(4-Iodo-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester

Downstream raw materials:

(1R,2S,3S,5S)-3-(4-Ethyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester

(1R,2S,3S,5S)-3-(4-Ethyl-3-iodo-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester

2β-carbomethoxy-3β-(4'-ethyl-3'-iodophenyl)nortropane