156496-01-4Relevant academic research and scientific papers
Synthesis and monoamine transporter affinity of new 2β-carbomethoxy- 3β-[aryl or heteroaryl]phenyltropanes
Tamagnan, Gilles,Alagille, David,Fu, Xing,Kula, Nora S.,Baldessarini, Ross J.,Innis, Robert B.,Baldwin, Ronald M.
, p. 217 - 220 (2007/10/03)
A series of 16 new 2β-carbomethoxy-3β-[aryl or heteroaryl]phenyltropane derivatives was synthesized and evaluated for binding to monoamine transporters. Most of the compounds exhibited nanomolar affinity for the serotonin transporter (SERT). Four compound
Synthesis and monoamine transporter affinity of new 2β-carbomethoxy- 3β-[4-(substituted thiophenyl)]phenyltropanes: Discovery of a selective SERT antagonist with picomolar potency
Tamagnan, Gilles,Alagille, David,Fu, Xing,Kula, Nora S.,Baldessarini, Ross J.,Innis, Robert B.,Baldwin, Ronald M.
, p. 1131 - 1133 (2007/10/03)
Preparation of cocaine analogues has been aimed largely at development of stable compounds with high affinity and selectivity for the dopamine transporter (DAT). We now report the synthesis and monoamine transporter affinity of 10 new 2β-carbomethoxy-3β-[
Synthesis and transporter binding properties of 3β-(4'-alkyl-, 4'- alkenyl-, and 4'-alkynylphenyl)nortropane-2β-carboxylic acid methyl esters: Serotonin transporter selective analogs
Blough, Bruce E.,Abraham, Philip,Lewin, Anita H.,Kuhar, Michael J.,Boja, John W.,Ivy Carroll
, p. 4027 - 4035 (2007/10/03)
New methods for the synthesis of 3β-(4'-alkyl-, 4'-alkenyl-, and 4'- alkynylphenyl)nortropane-2β-carboxylic acid methyl esters 2-4, respectively, were developed. These methods involved coupling of the appropriate organometallic reagents to 3β-(4'-iodophen
