2-(4-methyl)phenyl-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile

Base Information

• Chemical Name: 2-(4-methyl)phenyl-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile
• CAS No.: 1189050-60-9
• Molecular Formula: C₁₇H₁₆N₂
• Molecular Weight: 248.327
• Mol file: 1189050-60-9.mol

Synonyms:2-(4-methyl)phenyl-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile

Chemical Property of 2-(4-methyl)phenyl-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-(4-methyl)phenyl-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile

There total 17 articles about 2-(4-methyl)phenyl-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-(p-tolyl)-1,2,3,4-tetrahydroisoquinoline (78317-82-5) + trimethylsilyl cyanide (7677-24-9) → 2-(4-methyl)phenyl-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile (1189050-60-9)

Guidance literature:

With rose bengal; In acetonitrile; at 20 ℃; for 30h; Irradiation;

DOI:10.1039/c1gc15865a

Reference yield: 97.0%

2-(p-tolyl)-1,2,3,4-tetrahydroisoquinoline (78317-82-5) + P-toluenesulfonyl cyanide (19158-51-1) → 2-(4-methyl)phenyl-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile (1189050-60-9)

Guidance literature:

With tris[2-phenylpyridinato-C₂,N]iridium(III); In N,N-dimethyl acetamide; at 20 ℃; for 2h; Inert atmosphere; Irradiation;

DOI:10.1016/j.tetlet.2018.07.030

Reference yield: 97.0%

potassium cyanide + 2-(p-tolyl)-1,2,3,4-tetrahydroisoquinoline (78317-82-5) → 2-(4-methyl)phenyl-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile (1189050-60-9)

Guidance literature:

With [Ir(tbp-py)2(bpy)]PF₆; acetic acid; In acetonitrile; for 12h; Irradiation;

DOI:10.1039/c1cc15643h

upstream raw materials:

2-(p-tolyl)-1,2,3,4-tetrahydroisoquinoline

malononitrile

trimethylsilyl cyanide

sodium cyanide