2-Methoxy-5-[[tris(1-methylethyl)silyl]oxy]pyridine

Base Information

Chemical Name:2-Methoxy-5-[[tris(1-methylethyl)silyl]oxy]pyridine
CAS No.:867267-29-6
Molecular Formula:C₁₅H₂₇NO₂Si
Molecular Weight:281.47
Hs Code.:
DSSTox Substance ID:DTXSID401223734

Synonyms:2-Methoxy-5-[[tris(1-methylethyl)silyl]oxy]pyridine;DTXSID401223734;867267-29-6

Suppliers and Price of 2-Methoxy-5-[[tris(1-methylethyl)silyl]oxy]pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Methoxy-5-[[tris(1-methylethyl)silyl]oxy]pyridine

Chemical Property:

Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:281.181105638
Heavy Atom Count:19
Complexity:247

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)[Si](C(C)C)(C(C)C)OC1=CN=C(C=C1)OC

Technology Process of 2-Methoxy-5-[[tris(1-methylethyl)silyl]oxy]pyridine

There total 1 articles about 2-Methoxy-5-[[tris(1-methylethyl)silyl]oxy]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 51834-97-0
6-methoxypyridine-3-ol

: 13154-24-0
triisopropylsilyl chloride

: 867267-29-6
2-methoxy-5-(triisopropylsilanyloxy)pyridine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1055/s-2005-871946

Reference yield:

: 867267-29-6
2-methoxy-5-(triisopropylsilanyloxy)pyridine

: 867267-26-3
2,5-dimethoxy-pyridine-3-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: MeLi; diisopropylamine / tetrahydrofuran / 3 h / 0 °C

1.2: 64 percent / tetrahydrofuran / 2 h / -40 °C

2.1: 87 percent / TBAF / tetrahydrofuran / 2 h / 0 - 20 °C

3.1: K₂CO₃ / dimethylformamide / 3 h / 50 °C

With tetrabutyl ammonium fluoride; methyllithium; potassium carbonate; diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1055/s-2005-871946