C₄₂H₅₇O₆PS

Base Information

• Chemical Name: C₄₂H₅₇O₆PS
• CAS No.: 1332508-19-6
• Molecular Formula: C₄₂H₅₇O₆PS
• Molecular Weight: 720.951
• Mol file: 1332508-19-6.mol

Synonyms:C₄₂H₅₇O₆PS

Chemical Property of C₄₂H₅₇O₆PS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₂H₅₇O₆PS

There total 5 articles about C₄₂H₅₇O₆PS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1,2-O-isopropylidene-3-phenylsulfanyl-3-deoxy-α-D-xylofuranose (1332508-11-8) + 3,3',5,5'-tetra-tert-butyl-1,1'-biphenyl-2,2'-diyl phosphorochloridite (71941-98-5) → C42H57O6PS (1332508-19-6)

Guidance literature:

With pyridine; In toluene; at 80 ℃; for 1.5h;

DOI:10.1039/c1cc13300d

Reference yield:

1,2-O-isopropylidene-5-O-benzoyl-3-O-trifluoromethanesulfonyl-α-D-ribofuranose (1356929-41-3) → C42H57O6PS (1332508-19-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.03 h

1.2: 1.5 h / -78 °C

2.1: ammonia / methanol; water / 20 °C

3.1: pyridine / toluene / 1.5 h / 80 °C

With pyridine; ammonia; sodium hydride; In tetrahydrofuran; methanol; water; toluene;

DOI:10.1039/c1cc13300d

Reference yield:

((3aR,5R,65,6aR)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methyl benzoate (6612-91-5) → C42H57O6PS (1332508-19-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 2 h / -15 °C

2.1: sodium hydride / tetrahydrofuran / 0.03 h

2.2: 1.5 h / -78 °C

3.1: ammonia / methanol; water / 20 °C

4.1: pyridine / toluene / 1.5 h / 80 °C

With pyridine; ammonia; sodium hydride; In tetrahydrofuran; methanol; dichloromethane; water; toluene;

DOI:10.1039/c1cc13300d

upstream raw materials:

1,2-O-isopropylidene-5-O-benzoyl-3-O-trifluoromethanesulfonyl-α-D-ribofuranose

1,2-O-isopropylidene-5-O-benzoyl-3-phenylsulfanyl-3-deoxy-α-D-xylofuranose

1,2-O-isopropylidene-3-phenylsulfanyl-3-deoxy-α-D-xylofuranose

3,3',5,5'-tetra-tert-butyl-1,1'-biphenyl-2,2'-diyl phosphorochloridite

Refernces

• 1、 Coll, Mercedes,Pamies, Oscar,Dieguez, Montserrat. "Thioether-phosphite: New ligands for the highly enantioselective Ir-catalyzed hydrogenation of minimally functionalized olefins". . p. 9215 - 9217. Retrieved 2011/10/04.