methyl (1R,5R)-5-((S)-1-(4-methoxyphenoxy)propan-2-yl)-2-methylcyclohex-2-enylcarbamate

Base Information

Chemical Name:methyl (1R,5R)-5-((S)-1-(4-methoxyphenoxy)propan-2-yl)-2-methylcyclohex-2-enylcarbamate
CAS No.:1384835-04-4
Molecular Formula:C₁₉H₂₇NO₄
Molecular Weight:333.428
Hs Code.:

Synonyms:methyl (1R,5R)-5-((S)-1-(4-methoxyphenoxy)propan-2-yl)-2-methylcyclohex-2-enylcarbamate

Suppliers and Price of methyl (1R,5R)-5-((S)-1-(4-methoxyphenoxy)propan-2-yl)-2-methylcyclohex-2-enylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (1R,5R)-5-((S)-1-(4-methoxyphenoxy)propan-2-yl)-2-methylcyclohex-2-enylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (1R,5R)-5-((S)-1-(4-methoxyphenoxy)propan-2-yl)-2-methylcyclohex-2-enylcarbamate

There total 5 articles about methyl (1R,5R)-5-((S)-1-(4-methoxyphenoxy)propan-2-yl)-2-methylcyclohex-2-enylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1384835-03-3
2,2,2-trichloro-N-((1R,5R)-5-((S)-1-(4-methoxyphenoxy)propan-2-yl)-2-methylcyclohex-2-enyl)acetamide

: 149-73-5
trimethyl orthoformate

: 1384835-04-4
methyl (1R,5R)-5-((S)-1-(4-methoxyphenoxy)propan-2-yl)-2-methylcyclohex-2-enylcarbamate

Guidance literature:: trimethyl orthoformate; With toluene-4-sulfonic acid; In methanol; N,N-dimethyl-formamide; for 1h; Reflux; Inert atmosphere;

2,2,2-trichloro-N-((1R,5R)-5-((S)-1-(4-methoxyphenoxy)propan-2-yl)-2-methylcyclohex-2-enyl)acetamide; With sodium carbonate; In N,N-dimethyl-formamide; at 150 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jo300776d

Reference yield:

: 1384834-98-3
C₁₇H₂₄O₄S

: 1384835-04-4
methyl (1R,5R)-5-((S)-1-(4-methoxyphenoxy)propan-2-yl)-2-methylcyclohex-2-enylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

1.2: 16 h / 0 - 20 °C / Inert atmosphere

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.67 h / 0 °C / Inert atmosphere

2.2: 6 h / Reflux; Inert atmosphere

3.1: toluene-4-sulfonic acid / methanol; N,N-dimethyl-formamide / 1 h / Reflux; Inert atmosphere

3.2: 4 h / 150 °C / Inert atmosphere

With sodium hydride; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; dichloromethane; N,N-dimethyl-formamide; 2.1: Overman rearrangement / 2.2: Overman rearrangement;
DOI:10.1021/jo300776d

Reference yield:

: 552289-36-8
(1S,5S)-5-((S)-2-Hydroxy-1-methyl-ethyl)-2-methyl-cyclohex-2-enol

: 1384835-04-4
methyl (1R,5R)-5-((S)-1-(4-methoxyphenoxy)propan-2-yl)-2-methylcyclohex-2-enylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; dmap / chloroform / 30 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

2.2: 16 h / 0 - 20 °C / Inert atmosphere

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 1.67 h / 0 °C / Inert atmosphere

3.2: 6 h / Reflux; Inert atmosphere

4.1: toluene-4-sulfonic acid / methanol; N,N-dimethyl-formamide / 1 h / Reflux; Inert atmosphere

4.2: 4 h / 150 °C / Inert atmosphere

With pyridine; dmap; sodium hydride; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; 3.1: Overman rearrangement / 3.2: Overman rearrangement;
DOI:10.1021/jo300776d