Technology Process of 2'-DEOXY-4-DESMETHYLWYOSINE
There total 1 articles about 2'-DEOXY-4-DESMETHYLWYOSINE which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2'-Deoxyguanosine;
With
sodium hydride;
In
dimethyl sulfoxide;
at 20 ℃;
for 1h;
1-bromoacetone;
In
dimethyl sulfoxide;
at 20 ℃;
for 1h;
DOI:10.1055/s-2005-869905
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 80 percent / potassium carbonate / dimethylformamide / 6 h
2: 1.) N-bromosuccinimide, 20percent aq. 0.2 M acetate buffer, 2.) conc. ammonia / 1.) dimethyl sulfoxide, 15 min, 2.) 15 min
3: 52 percent / pyridine / 2 h
With
pyridine; ammonium hydroxide; N-Bromosuccinimide; 0.2 M acetate buffer; potassium carbonate;
In
N,N-dimethyl-formamide;
DOI:10.1021/ja00169a039
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 80 percent / potassium carbonate / dimethylformamide / 6 h
2: 1.) N-bromosuccinimide, 20percent aq. 0.2 M acetate buffer, 2.) conc. ammonia / 1.) dimethyl sulfoxide, 15 min, 2.) 15 min
3: 52 percent / pyridine / 2 h
4: 53 percent / diisopropylethylamine / CH2Cl2 / 1 h
With
pyridine; ammonium hydroxide; N-Bromosuccinimide; 0.2 M acetate buffer; potassium carbonate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00169a039
