trans-[4-(4-indazol-1-yl-pyrimidin-2-ylamino)-cyclohexyl]-morpholin-4-yl-methanone

Base Information

Chemical Name:trans-[4-(4-indazol-1-yl-pyrimidin-2-ylamino)-cyclohexyl]-morpholin-4-yl-methanone
CAS No.:1032452-37-1
Molecular Formula:C₂₂H₂₆N₆O₂
Molecular Weight:406.487
Hs Code.:

Synonyms:trans-[4-(4-indazol-1-yl-pyrimidin-2-ylamino)-cyclohexyl]-morpholin-4-yl-methanone

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Chemical Property of trans-[4-(4-indazol-1-yl-pyrimidin-2-ylamino)-cyclohexyl]-morpholin-4-yl-methanone

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Technology Process of trans-[4-(4-indazol-1-yl-pyrimidin-2-ylamino)-cyclohexyl]-morpholin-4-yl-methanone

There total 3 articles about trans-[4-(4-indazol-1-yl-pyrimidin-2-ylamino)-cyclohexyl]-morpholin-4-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1032452-66-6
1-(2-methanesulfonyl-pyrimidin-4-yl)-1H-indazole

: 412291-29-3
trans-(4-amino-cyclohexyl)-morpholin-4-yl-methanone

: 1032452-37-1
trans-[4-(4-indazol-1-yl-pyrimidin-2-ylamino)-cyclohexyl]-morpholin-4-yl-methanone

Guidance literature:: trans-(4-amino-cyclohexyl)-morpholin-4-yl-methanone; With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 120 ℃;

1-(2-methanesulfonyl-pyrimidin-4-yl)-1H-indazole; In 1-methyl-pyrrolidin-2-one; at 20 - 120 ℃; for 51h;

Reference yield:

: 271-44-3
benzimidazole

: 1032452-37-1
trans-[4-(4-indazol-1-yl-pyrimidin-2-ylamino)-cyclohexyl]-morpholin-4-yl-methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 2.5 h / 20 - 70 °C

2.1: 3-chloro-benzenecarboperoxoic acid / chloroform / Cooling with acetone-dry ice

3.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 120 °C

3.2: 51 h / 20 - 120 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In 1-methyl-pyrrolidin-2-one; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 1032451-38-9
1-(2-methylsulfanyl-pyrimidin-4-yl)-1H-indazole

: 1032452-37-1
trans-[4-(4-indazol-1-yl-pyrimidin-2-ylamino)-cyclohexyl]-morpholin-4-yl-methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 3-chloro-benzenecarboperoxoic acid / chloroform / Cooling with acetone-dry ice

2.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 120 °C

2.2: 51 h / 20 - 120 °C

With N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In 1-methyl-pyrrolidin-2-one; chloroform;