8-methoxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Base Information

Chemical Name:8-methoxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS No.:116263-67-3
Molecular Formula:C₁₈H₂₂N₂O
Molecular Weight:282.385
Hs Code.:

Synonyms:8-methoxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-methoxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

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Technology Process of 8-methoxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

There total 6 articles about 8-methoxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 116234-47-0
8-methoxy-3-methyl-1-(4'-nitrophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

: 116263-67-3
8-methoxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: With nickel; hydrazine hydrate; In ethanol; at 50 - 55 ℃;
DOI:10.1021/jm00164a009

Reference yield: 87.0%

: 116263-67-3
8-methoxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: In methanol; water;

Reference yield:

: 6388-74-5,38201-14-8,71884-55-4
p-Nitrophenyloxirane

: 116263-67-3
8-methoxy-3-methyl-1-(4'-aminophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / tetrahydrofuran / 24 h / Heating

2: 91 percent / PPA / 2 h / 100 °C

3: 92 percent / 88percent formic acid / H₂O / 24 h / Heating

4: 92 percent / hydrazine hydrate, Raney nickel / ethanol / 50 - 55 °C

With formic acid; nickel; hydrazine hydrate; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jm00164a009