(2R,4S)-4-Hydroxy-1-[4-(2,2,2-trifluoro-ethoxy)-phenylcarbamoyl]-pyrrolidine-2-carboxylic acid methyl ester

Base Information

Chemical Name:(2R,4S)-4-Hydroxy-1-[4-(2,2,2-trifluoro-ethoxy)-phenylcarbamoyl]-pyrrolidine-2-carboxylic acid methyl ester
CAS No.:1408313-90-5
Molecular Formula:C₁₅H₁₇F₃N₂O₅
Molecular Weight:362.306
Hs Code.:

Synonyms:(2R,4S)-4-Hydroxy-1-[4-(2,2,2-trifluoro-ethoxy)-phenylcarbamoyl]-pyrrolidine-2-carboxylic acid methyl ester

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Chemical Property of (2R,4S)-4-Hydroxy-1-[4-(2,2,2-trifluoro-ethoxy)-phenylcarbamoyl]-pyrrolidine-2-carboxylic acid methyl ester

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Technology Process of (2R,4S)-4-Hydroxy-1-[4-(2,2,2-trifluoro-ethoxy)-phenylcarbamoyl]-pyrrolidine-2-carboxylic acid methyl ester

There total 4 articles about (2R,4S)-4-Hydroxy-1-[4-(2,2,2-trifluoro-ethoxy)-phenylcarbamoyl]-pyrrolidine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 481704-21-6
(2R,4S)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride

: 110855-51-1
1-Isocyanato-4-(2,2,2-trifluoro-ethoxy)-benzene

: 1408313-90-5
(2R,4S)-4-Hydroxy-1-[4-(2,2,2-trifluoro-ethoxy)-phenylcarbamoyl]-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: (2R,4S)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride; With sodium carbonate; In tetrahydrofuran; for 0.25h;

1-Isocyanato-4-(2,2,2-trifluoro-ethoxy)-benzene; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1408313-90-5
(2R,4S)-4-Hydroxy-1-[4-(2,2,2-trifluoro-ethoxy)-phenylcarbamoyl]-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.5 h / 0 °C

1.2: 2 h / 5 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h / 0 °C / Inert atmosphere

3.1: sodium hydrogencarbonate / dichloromethane / 0.17 h / Inert atmosphere

3.2: 0.17 h / 10 °C

4.1: sodium carbonate / tetrahydrofuran / 0.25 h

4.2: 2 h / 20 °C

With hydrogen; sodium hydride; sodium hydrogencarbonate; sodium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; oil;

Reference yield:

: 62149-35-3
1-(2,2,2-trifluoroethoxy)-4-nitrobenzene

: 1408313-90-5
(2R,4S)-4-Hydroxy-1-[4-(2,2,2-trifluoro-ethoxy)-phenylcarbamoyl]-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h / 0 °C / Inert atmosphere

2.1: sodium hydrogencarbonate / dichloromethane / 0.17 h / Inert atmosphere

2.2: 0.17 h / 10 °C

3.1: sodium carbonate / tetrahydrofuran / 0.25 h

3.2: 2 h / 20 °C

With hydrogen; sodium hydrogencarbonate; sodium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;