110855-51-1

Basic information

• Product Name: 1-Isocyanato-4-(2,2,2-trifluoro-ethoxy)-benzene
• Synonyms: 1-Isocyanato-4-(2,2,2-trifluoro-ethoxy)-benzene
• CAS NO: 110855-51-1
• Molecular Weight: 217.147
• Mol File: 110855-51-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Isocyanato-4-(2,2,2-trifluoro-ethoxy)-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Isocyanato-4-(2,2,2-trifluoro-ethoxy)-benzene(110855-51-1)
• EPA Substance Registry System: 1-Isocyanato-4-(2,2,2-trifluoro-ethoxy)-benzene(110855-51-1)

Safety Data

• Hazardous Substances Data: 110855-51-1(Hazardous Substances Data)

Upstream product

• 27914-56-3 4-(2,2,2-trifluoroethoxy)benzoic acid 
• 62149-35-3 1-(2,2,2-trifluoroethoxy)-4-nitrobenzene 
• 350-46-9 4-Fluoronitrobenzene 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 57946-61-9 4-(2,2,2,-trifluoroethoxy)aniline 
• 36844-44-7 ethyl 4-(2,2,2-trifluoroethoxy)benzoate 
• 451-46-7 4-fluorobenzoic acid ethyl ester 

Downstream Products

• 1408313-90-5 (2R,4S)-4-Hydroxy-1-[4-(2,2,2-trifluoro-ethoxy)-phenylcarbamoyl]-pyrrolidine-2-carboxylic acid methyl ester 
• 1408313-89-2 (6S,7aR)-6-(3-Methyl-butoxy)-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one 
• 1408313-91-6 (2R,4S)-4-(tert-Butyl-diphenyl-silanyloxy)-1-[4-(2,2,2-trifluoro-ethoxy)-phenylcarbamoyl]-pyrrolidine-2-carboxylic acid methyl ester 
• 1408313-93-8 (6S,7aR)-6-(tert-Butyl-diphenyl-silanyloxy)-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one 
• 1408313-94-9 (6S,7aR)-6-Hydroxy-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one 
• 1408313-97-2 (6R,7aR)-6-Bromo-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-3-one 
• 1408313-96-1 2-chloro-N-{(6S,7aR)-3-oxo-2-[4-(2,2,2-trifluoro-ethoxy)-phenyl]-hexahydro-pyrrolo[1,2-c]imidazol-6-yl}-benzenesulfonamide 
• 1408313-92-7 (2R,4S)-4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxymethyl-pyrrolidine-1-carboxylic acid [4-(2,2,2-trifluoro-ethoxy)-phenyl]-amide 
• 155432-24-9 1-[(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl]-4-[4-(2,2,2-trifluoroethoxy)phenyl]-5(1H,4H)-tetrazolone 

Relevant articles and documents

NEW HEXAHYDROPYRROLOIMIDAZOLONE COMPOUNDS

The invention provides novel compounds having the general formula (I), wherein R1, R2, R3 and A are as described herein, compositions including the compounds and methods of using the compounds. These compounds are useful as inhibitors of hormone sensitive

Optically active antifungal azoles. VI. Synthesis and antifungal activity of N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl) propyl]-N′-(4-substituted phenyl)-3(2H,4H)-1,2,4-triazolones and 5(1H,4H)-tetrazolones

A new series of optically active antifungal azoles, N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl) propyl]-N′-(4-substituted phenyl)-3(2H,4H)-1,2,4-triazolones (1,2) and 5(1H,4H)-tetrazolones (3), were prepared from the triflate derivative of (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol (13) by an SN2 displacement reaction with the union of an azolone (17-19) and subsequent ring-opening reaction with 1H-1,2,4-triazole. The optically active oxiranylethanol 13 was synthesized from methyl (R)-lactate in a stereocontrolled manner. The azolones 1-3 prepared showed potent antifungal activities in vitro and in vivo.