pentacarbonyl{((2R,5S)-1-aza-2-isopropyl-3-oxa-5-phenylcyclopentyl)(methyl)carbene}chromium⁽⁰⁾

Base Information

• Chemical Name: pentacarbonyl{((2R,5S)-1-aza-2-isopropyl-3-oxa-5-phenylcyclopentyl)(methyl)carbene}chromium⁽⁰⁾
• CAS No.: 124685-69-4
• Molecular Formula: C₁₉H₁₉CrNO₆
• Molecular Weight: 409.359
• Mol file: 124685-69-4.mol

Synonyms:pentacarbonyl{((2R,5S)-1-aza-2-isopropyl-3-oxa-5-phenylcyclopentyl)(methyl)carbene}chromium⁽⁰⁾

Chemical Property of pentacarbonyl{((2R,5S)-1-aza-2-isopropyl-3-oxa-5-phenylcyclopentyl)(methyl)carbene}chromium⁽⁰⁾

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of pentacarbonyl{((2R,5S)-1-aza-2-isopropyl-3-oxa-5-phenylcyclopentyl)(methyl)carbene}chromium⁽⁰⁾

There total 1 articles about pentacarbonyl{((2R,5S)-1-aza-2-isopropyl-3-oxa-5-phenylcyclopentyl)(methyl)carbene}chromium⁽⁰⁾ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.5%

pentacarbonyl((methyl)((tetramethylammonio)oxy)carbene)chromium(0) (15975-93-6) + (4S)-2-isopropyl-4-phenyl-1,3-oxazolidine (188661-46-3) → pentacarbonyl{((2R,5S)-1-aza-2-isopropyl-3-oxa-5-phenylcyclopentyl)(methyl)carbene}chromium(0) (124685-69-4)

Guidance literature:

With Acetyl bromide; In dichloromethane; Ar, deoxygenated soln. of complex is cooled to -40°C, CH3COBr is added, stirring 1 h at -40°C; 4:1-diastereomeric mixt. of oxazolidine is prepd. from (S)-phenylglycinol and CH(CH3)2CHO, added to acetoxycarbene soln., warming overnight; addn. of sodium bicarbonate, extn. (CH2Cl2), drying (MgSO4), filtn. (Celite, silica gel), concn. in vacuo, triturating in hexane, recrystn. (ethyl acetate/hexane); NOE, elem. anal.;

Reference yield: 100.0%

pentacarbonyl{((2R,5S)-1-aza-2-isopropyl-3-oxa-5-phenylcyclopentyl)(methyl)carbene}chromium(0) (124685-69-4) → methyl 2-(1-aza-2R-isopropyl-3-oxa-5S-phenylcyclopentyl)propanoate + chromium(0) hexacarbonyl (199620-14-9,13007-92-6)

Guidance literature:

With methanol; In methanol; Irradiation (UV/VIS); solid carbene complex in dry methanol is added to an oven-dried Pyrex pressure tube, contents are degassed, purged with Ar, warmed to room temp., purged with CO, pressurized with 50-90 psi CO, irradiated (450 W) for 18 h; mixt. of two diastereoisomers, noted in H-NMR as a 87:13 ratio; IR, elem. anal.;

Reference yield: 81.0%

pentacarbonyl{((2R,5S)-1-aza-2-isopropyl-3-oxa-5-phenylcyclopentyl)(methyl)carbene}chromium(0) (124685-69-4) + tert-butyl alcohol (75-65-0) → t-butyl 2-(1-aza-2R-isopropyl-3-oxa-5S-phenylcyclopentyl)propanoate + chromium(0) hexacarbonyl (199620-14-9,13007-92-6)

Guidance literature:

In tert-butyl alcohol; Irradiation (UV/VIS); solid carbene complex in dry tBuOH is added to an oven-dried Pyrex pressure tube, contents are degassed, purged with Ar, warmed to room temp., purged with CO, pressurized with 50-90 psi CO, irradiated (450 W); mixt. of two diastereoisomers, 42 % de by H-NMR; IR, elem. anal.;

upstream raw materials:

pentacarbonyl((methyl)((tetramethylammonio)oxy)carbene)chromium⁽⁰⁾

(4S)-2-isopropyl-4-phenyl-1,3-oxazolidine

Downstream raw materials:

chromium⁽⁰⁾ hexacarbonyl