C₁₂H₁₂O₃C₄H₂

Base Information

• Chemical Name: C₁₂H₁₂O₃C₄H₂
• CAS No.: 933791-92-5
• Molecular Formula: C₁₆H₁₄O₃
• Molecular Weight: 254.285
• Mol file: 933791-92-5.mol

Synonyms:C₁₂H₁₂O₃C₄H₂

Chemical Property of C₁₂H₁₂O₃C₄H₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₂O₃C₄H₂

There total 5 articles about C₁₂H₁₂O₃C₄H₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H16O4 (151588-91-9) → C12H12O3C4H2 (933791-92-5)

Guidance literature:

C₁₆H₁₆O₄; With dmap; triethylamine; p-toluenesulfonyl chloride; In dichloromethane; at 20 ℃; for 3h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 4h; Further stages.;

DOI:10.1002/anie.200604977

Reference yield:

5-hydroxy-5-phenyl-2,2-dimethyl-1,3-dioxane (162821-38-7) → C12H12O3C4H2 (933791-92-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: aq. HCl / methanol / 6 h / 20 °C

2.1: (R,R)-(t-Bu)CH(4-Bn-4,5-H₂-1,3-oxazol-2-yl)N=CHC₆H₂(t-Bu)2OH; Et₃N; CuCl₂ / tetrahydrofuran / 1 h / 20 °C

3.1: TsCl; Et₃N; 4-dimethylaminopyridine / CH₂Cl₂ / 3 h / 20 °C

3.2: DBU / CH₂Cl₂ / 4 h / 20 °C

With hydrogenchloride; dmap; triethylamine; p-toluenesulfonyl chloride; copper dichloride; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1002/anie.200604977

Reference yield:

benzoyl chloride (98-88-4) → C12H12O3C4H2 (933791-92-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: (R,R)-(t-Bu)CH(4-Bn-4,5-H₂-1,3-oxazol-2-yl)N=CHC₆H₂(t-Bu)2OH; Et₃N; CuCl₂ / tetrahydrofuran / 1 h / 20 °C

2.1: TsCl; Et₃N; 4-dimethylaminopyridine / CH₂Cl₂ / 3 h / 20 °C

2.2: DBU / CH₂Cl₂ / 4 h / 20 °C

With dmap; triethylamine; p-toluenesulfonyl chloride; copper dichloride; In tetrahydrofuran; dichloromethane;

DOI:10.1002/anie.200604977

upstream raw materials:

C₁₆H₁₆O₄

5-hydroxy-5-phenyl-2,2-dimethyl-1,3-dioxane

benzoyl chloride

2-phenylglycerol

Downstream raw materials:

(S)-(2-phenyloxiran-2-yl)methanol