Technology Process of benzyl [3-fluoro-4-(4-hydroxymethyl-oxazol-2-yl)-phenyl]-carbamate
There total 8 articles about benzyl [3-fluoro-4-(4-hydroxymethyl-oxazol-2-yl)-phenyl]-carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 2-(4-benzyloxycarbonylamino-2-fluoro-phenyl)-4,5-oxazole-4-carboxylate;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
for 0.166667h;
With
water;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: chromium(VI) oxide; sulfuric acid; acetic acid / water / 3 h / 100 °C
2.1: triethylamine / dmap / dichloromethane / 2 h / 10 - 20 °C
3.1: iron; ammonium chloride / ethanol; water / 1 h / 95 °C
4.1: sodium hydrogencarbonate / tetrahydrofuran / 19 h / 0 - 50 °C
5.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C
6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C
7.1: Burgess Reagent / tetrahydrofuran / 3 h / 75 °C
8.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 0 °C
8.2: 0.5 h / 0 °C
With
chromium(VI) oxide; lithium aluminium tetrahydride; Burgess Reagent; sulfuric acid; iron; sodium hydrogencarbonate; ammonium chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
dmap;
In
tetrahydrofuran; ethanol; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: triethylamine / dmap / dichloromethane / 2 h / 10 - 20 °C
2.1: iron; ammonium chloride / ethanol; water / 1 h / 95 °C
3.1: sodium hydrogencarbonate / tetrahydrofuran / 19 h / 0 - 50 °C
4.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C
5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C
6.1: Burgess Reagent / tetrahydrofuran / 3 h / 75 °C
7.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 0 °C
7.2: 0.5 h / 0 °C
With
lithium aluminium tetrahydride; Burgess Reagent; iron; sodium hydrogencarbonate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
dmap;
In
tetrahydrofuran; ethanol; dichloromethane; water;
