N-tert-butoxycarbonylbenzamido-methoxycarbonylethyl-1,4,7-triaza cyclononane

Base Information

• Chemical Name: N-tert-butoxycarbonylbenzamido-methoxycarbonylethyl-1,4,7-triaza cyclononane
• CAS No.: 1609973-70-7
• Molecular Formula: C₂₂H₃₄N₄O₅
• Molecular Weight: 434.536
• Mol file: 1609973-70-7.mol

Synonyms:N-tert-butoxycarbonylbenzamido-methoxycarbonylethyl-1,4,7-triaza cyclononane

Chemical Property of N-tert-butoxycarbonylbenzamido-methoxycarbonylethyl-1,4,7-triaza cyclononane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tert-butoxycarbonylbenzamido-methoxycarbonylethyl-1,4,7-triaza cyclononane

There total 1 articles about N-tert-butoxycarbonylbenzamido-methoxycarbonylethyl-1,4,7-triaza cyclononane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

1,4,7-triazacyclononane (4730-54-5) + Bz-ΔAla(N-Boc)-OMe (257955-17-2) → N-tert-butoxycarbonylbenzamido-methoxycarbonylethyl-1,4,7-triaza cyclononane (1609973-70-7)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 3h;

DOI:10.1039/c4dt00386a

Reference yield:

N-tert-butoxycarbonylbenzamido-methoxycarbonylethyl-1,4,7-triaza cyclononane (1609973-70-7) → benzamido-methoxycarbonylethyl-4,7-bis-(ethoxycarbonylmethyl)-1,4,7-triaza cyclononane (1609973-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: potassium carbonate / acetonitrile / 2.5 h / 20 °C

With potassium carbonate; trifluoroacetic acid; In dichloromethane; acetonitrile;

DOI:10.1039/c4dt00386a

Reference yield:

N-tert-butoxycarbonylbenzamido-methoxycarbonylethyl-1,4,7-triaza cyclononane (1609973-70-7) → benzamido-carboxyethyl-4,7-bis-(carboxymethyl)-1,4,7-triazacyclononane hydrochloride

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: potassium carbonate / acetonitrile / 2.5 h / 20 °C

3: Dowex-1X2-100-OH? resin / water; ethanol / 2 h / 20 °C / pH 10

With potassium carbonate; trifluoroacetic acid; In ethanol; dichloromethane; water; acetonitrile;

DOI:10.1039/c4dt00386a

upstream raw materials:

1,4,7-triazacyclononane

Bz-ΔAla(N-Boc)-OMe

Downstream raw materials:

benzamido-methoxycarbonylethyl-4,7-bis-(ethoxycarbonylmethyl)-1,4,7-triaza cyclononane

Ga[benzamido-carboxyethyl-4,7-bis-(carboxymethyl)-1,4,7-triazacyclononane-3H]