3-BROMO-2,5,6-TRIMETHOXYBENZOIC ACID

Base Information

• Chemical Name: 3-BROMO-2,5,6-TRIMETHOXYBENZOIC ACID
• CAS No.: 101460-22-4
• Molecular Formula: C10H11 Br O5
• Molecular Weight: 291.098
• Hs Code.: 2918990090
• Mol file: 101460-22-4.mol

Synonyms:3-Bromo-2,5,6-trimethoxybenzoicacid

Chemical Property of 3-BROMO-2,5,6-TRIMETHOXYBENZOIC ACID

Chemical Property:

• Vapor Pressure: 1.85E-06mmHg at 25°C
• Melting Point: 96 °C
• Refractive Index: 1.553
• Boiling Point: 380.2°C at 760 mmHg
• Flash Point: 183.7°C
• PSA: 64.99000
• Density: 1.53g/cm³
• LogP: 2.17310
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-2,5,6-trimethoxybenzoic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMO-2,5,6-TRIMETHOXYBENZOIC ACID

There total 2 articles about 3-BROMO-2,5,6-TRIMETHOXYBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3,6-trimethoxybenzoic acid (60241-74-9) → 3-bromo-2,5,6-trimethoxybenzoic acid (101460-22-4)

Guidance literature:

With bromine; In 1,4-dioxane; for 1h; Yield given; Ambient temperature;

DOI:10.1021/jm00166a012

Reference yield:

1,2,4-trimethoxy-benzene (135-77-3) → 3-bromo-2,5,6-trimethoxybenzoic acid (101460-22-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, 20 deg C, 2.) Et₂O

2: Br₂ / dioxane / 1 h / Ambient temperature

With n-butyllithium; bromine; In 1,4-dioxane;

DOI:10.1021/jm00166a012

Reference yield:

3-bromo-2,5,6-trimethoxybenzoic acid (101460-22-4) → 3-Bromo-2,5,6-trimethoxy-benzoyl chloride (101460-33-7)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In toluene; at 60 ℃; for 1h;

DOI:10.1021/jm00166a012

upstream raw materials:

2,3,6-trimethoxybenzoic acid

1,2,4-trimethoxy-benzene

Downstream raw materials:

3-Bromo-2,5,6-trimethoxy-benzoyl chloride

(R)-(+)-N-[(1-benzyl-2-pyrrolidinyl)methyl]-3-bromo-2-hydroxy-5,6-dimethoxybenzamide

N-((R)-1-Benzyl-pyrrolidin-2-ylmethyl)-3-bromo-2,5,6-trimethoxy-benzamide

3-Bromo-N-[(R)-1-(4-fluoro-benzyl)-pyrrolidin-2-ylmethyl]-6-hydroxy-2,5-dimethoxy-benzamide