N-((R)-1-Benzyl-pyrrolidin-2-ylmethyl)-3-bromo-2,5,6-trimethoxy-benzamide

Base Information

Chemical Name:N-((R)-1-Benzyl-pyrrolidin-2-ylmethyl)-3-bromo-2,5,6-trimethoxy-benzamide
CAS No.:101460-32-6
Molecular Formula:C₂₂H₂₇BrN₂O₄
Molecular Weight:463.371
Hs Code.:

Synonyms:N-((R)-1-Benzyl-pyrrolidin-2-ylmethyl)-3-bromo-2,5,6-trimethoxy-benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((R)-1-Benzyl-pyrrolidin-2-ylmethyl)-3-bromo-2,5,6-trimethoxy-benzamide

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Technology Process of N-((R)-1-Benzyl-pyrrolidin-2-ylmethyl)-3-bromo-2,5,6-trimethoxy-benzamide

There total 2 articles about N-((R)-1-Benzyl-pyrrolidin-2-ylmethyl)-3-bromo-2,5,6-trimethoxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 101460-22-4
3-bromo-2,5,6-trimethoxybenzoic acid

: 101460-32-6
N-((R)-1-Benzyl-pyrrolidin-2-ylmethyl)-3-bromo-2,5,6-trimethoxy-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride, DMF, / toluene / 3 h / 60 °C

2: CH₂Cl₂ / Ambient temperature

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; toluene;
DOI:10.1021/jm00107a012

Reference yield:

: 101460-33-7
3-Bromo-2,5,6-trimethoxy-benzoyl chloride

: 101540-53-8
(S)-1-benzyl-2-pyrrolidinylmethylamine

: 101460-32-6
N-((R)-1-Benzyl-pyrrolidin-2-ylmethyl)-3-bromo-2,5,6-trimethoxy-benzamide

Guidance literature:: In dichloromethane; Yield given; Ambient temperature;
DOI:10.1021/jm00107a012

Reference yield: 49.0%

: 101460-32-6
N-((R)-1-Benzyl-pyrrolidin-2-ylmethyl)-3-bromo-2,5,6-trimethoxy-benzamide

: 101460-54-2
(R)-(+)-N-[(1-benzyl-2-pyrrolidinyl)methyl]-3-bromo-2-hydroxy-5,6-dimethoxybenzamide

Guidance literature:: With hydrogenchloride; boron tribromide; In diethyl ether; dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/jm00107a012