7-Quinazolinamine (9CI)

Base Information

• Chemical Name: 7-Quinazolinamine (9CI)
• CAS No.: 101421-73-2
• Molecular Formula: C8H7N3
• Molecular Weight: 145.16128
• Hs Code.: 2933990090
• Mol file: 101421-73-2.mol

Synonyms:Quinazoline,7-amino- (6CI);7-Aminoquinazoline;

Chemical Property of 7-Quinazolinamine (9CI)

Chemical Property:

• Melting Point: 190-191 °C(Solv: benzene (71-43-2))
• Boiling Point: 335.935 °C at 760 mmHg
• PKA: 3.60±0.70(Predicted)
• Flash Point: 183.492 °C
• PSA: 51.80000
• Density: 1.293g/cm³
• LogP: 1.79320
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

Quinazolin-7-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Quinazolinamine (9CI)

There total 5 articles about 7-Quinazolinamine (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

hexamethylenetetramine (100-97-0) + ethyl N-(3-ethoxycarbonylaminophenyl)carbamate (7450-61-5) → 7-aminoquinazoline (101421-73-2)

Guidance literature:

hexamethylenetetramine; ethyl N-(3-ethoxycarbonylaminophenyl)carbamate; With trifluoroacetic acid; for 1h; Heating;

With potassium hydroxide; potassium hexacyanoferrate(III); In ethanol; water; for 4h; Heating;

DOI:10.1016/j.tet.2006.09.103

Reference yield:

(NHCO2C2H5)C8H6N2CO2C2H5 → 7-aminoquinazoline (101421-73-2)

Guidance literature:

With potassium hydroxide; potassium hexacyanoferrate(III); In ethanol; water; at 100 ℃; for 0.5h; microwave irradiation;

DOI:10.1016/j.tetlet.2007.03.027

Reference yield:

4-chloro-7-nitroquinazoline (19815-17-9) → 7-aminoquinazoline (101421-73-2)

Guidance literature:

With methanol; Lindlar's catalyst; Hydrogenation.und anschliessenden Dehydrierung mit wss.K3;

DOI:10.1021/ja01147a527

upstream raw materials:

4-chloro-7-nitroquinazoline

hexamethylenetetramine

ethyl N-(3-ethoxycarbonylaminophenyl)carbamate

m-phenylenediamine

Refernces

• 1、 Chilin, Adriana,Marzaro, Giovanni,Zanatta, Samuele,Guiotto, Adriano. "A microwave improvement in the synthesis of the quinazoline scaffold". . p. 3229 - 3231. Retrieved 2008/02/02.