Technology Process of C28H26N2O2S
There total 12 articles about C28H26N2O2S which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 400 g / CF3COOH / methanol; CH2Cl2 / 240 h / 20 °C
2.1: NaH / methanol; toluene / 72 h / Heating
2.2: 80 percent / CH3COOH; HCl / methanol; toluene; H2O / 10 h / Heating
3.1: iPr2NH; n-BuLi / tetrahydrofuran / 0.5 h / -78 °C
3.2: tetrahydrofuran / 3 h / -78 - 20 °C
3.3: KOH / tetrahydrofuran; H2O / 16 h / 20 °C
With
n-butyllithium; sodium hydride; diisopropylamine; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
1.1: Pictet-Spengler reaction / 2.1: Dieckmann cyclization;
DOI:10.1021/jo030006h
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: NaH / methanol; toluene / 72 h / Heating
1.2: 80 percent / CH3COOH; HCl / methanol; toluene; H2O / 10 h / Heating
2.1: iPr2NH; n-BuLi / tetrahydrofuran / 0.5 h / -78 °C
2.2: tetrahydrofuran / 3 h / -78 - 20 °C
2.3: KOH / tetrahydrofuran; H2O / 16 h / 20 °C
With
n-butyllithium; sodium hydride; diisopropylamine;
In
tetrahydrofuran; methanol; toluene;
1.1: Dieckmann cyclization;
DOI:10.1021/jo030006h
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: methanol / 5 h / 20 °C
2.1: NaBH4 / methanol / 4 h / -5 °C
3.1: 400 g / CF3COOH / methanol; CH2Cl2 / 240 h / 20 °C
4.1: NaH / methanol; toluene / 72 h / Heating
4.2: 80 percent / CH3COOH; HCl / methanol; toluene; H2O / 10 h / Heating
5.1: iPr2NH; n-BuLi / tetrahydrofuran / 0.5 h / -78 °C
5.2: tetrahydrofuran / 3 h / -78 - 20 °C
5.3: KOH / tetrahydrofuran; H2O / 16 h / 20 °C
With
sodium tetrahydroborate; n-butyllithium; sodium hydride; diisopropylamine; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
3.1: Pictet-Spengler reaction / 4.1: Dieckmann cyclization;
DOI:10.1021/jo030006h
