Benzimidazole, 4-amino-6-methoxy- (6CI)

Base Information

• Chemical Name: Benzimidazole, 4-amino-6-methoxy- (6CI)
• CAS No.: 101257-95-8
• Molecular Formula: C₈H₉N₃O
• Molecular Weight: 163.179
• Mol file: 101257-95-8.mol

Synonyms:Benzimidazole,4-amino-6-methoxy- (6CI)

Chemical Property of Benzimidazole, 4-amino-6-methoxy- (6CI)

Chemical Property:

• Boiling Point: 499.2±25.0 °C(Predicted)
• PKA: 14.77±0.30(Predicted)
• PSA: 63.93000
• Density: 1.344±0.06 g/cm3(Predicted)
• LogP: 1.73490

Purity/Quality:

98%min ^*data from raw suppliers

4-Amino-6-methoxy-1H-benzimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzimidazole, 4-amino-6-methoxy- (6CI)

There total 3 articles about Benzimidazole, 4-amino-6-methoxy- (6CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-methoxy-4-nitro-1(3)H-benzoimidazole (64457-68-7) → 6-methoxy-1(3)H-benzimidazol-4-ylamine (101257-95-8)

Guidance literature:

With methanol; nickel; Hydrogenation;

DOI:10.1039/jr9460000092

Reference yield:

4-amino-1-methoxy-3,5-dinitrobenzene (5350-56-1) → 6-methoxy-1(3)H-benzimidazol-4-ylamine (101257-95-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen sulfide; aq.-ethanolic ammonia

2: aqueous HCl

3: Raney nickel; methanol / Hydrogenation

With hydrogenchloride; methanol; ammonium hydroxide; hydrogen sulfide; nickel;

DOI:10.1039/jr9460000092

Reference yield:

5-methoxy-3-nitrobenzene-1,2-diamine (76179-57-2) → 6-methoxy-1(3)H-benzimidazol-4-ylamine (101257-95-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous HCl

2: Raney nickel; methanol / Hydrogenation

With hydrogenchloride; methanol; nickel;

DOI:10.1039/jr9460000092

upstream raw materials:

6-methoxy-4-nitro-1⁽³⁾H-benzoimidazole

4-amino-1-methoxy-3,5-dinitrobenzene

5-methoxy-3-nitrobenzene-1,2-diamine

Downstream raw materials:

N-(6-methoxy-1⁽³⁾H-benzimidazol-4-yl)-toluene-4-sulfonamide