tert-butyl [(tert-butoxycarbonyl)amino](3-{[1-{[cyclohexyl(methyl)amino]carbonyl}-2-(2-naphthylsulfonyl)hydrazino]methyl}-1-piperidinyl)methylidenecarbamate

Base Information

Chemical Name:tert-butyl [(tert-butoxycarbonyl)amino](3-{[1-{[cyclohexyl(methyl)amino]carbonyl}-2-(2-naphthylsulfonyl)hydrazino]methyl}-1-piperidinyl)methylidenecarbamate
CAS No.:939796-85-7
Molecular Formula:C₃₅H₅₂N₆O₇S
Molecular Weight:700.9
Hs Code.:

tert-butyl [(tert-butoxycarbonyl)amino](3-{[1-{[cyclohexyl(methyl)amino]carbonyl}-2-(2-naphthylsulfonyl)hydrazino]methyl}-1-piperidinyl)methylidenecarbamate

Synonyms:tert-butyl [(tert-butoxycarbonyl)amino](3-{[1-{[cyclohexyl(methyl)amino]carbonyl}-2-(2-naphthylsulfonyl)hydrazino]methyl}-1-piperidinyl)methylidenecarbamate

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Chemical Property of tert-butyl [(tert-butoxycarbonyl)amino](3-{[1-{[cyclohexyl(methyl)amino]carbonyl}-2-(2-naphthylsulfonyl)hydrazino]methyl}-1-piperidinyl)methylidenecarbamate

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Technology Process of tert-butyl [(tert-butoxycarbonyl)amino](3-{[1-{[cyclohexyl(methyl)amino]carbonyl}-2-(2-naphthylsulfonyl)hydrazino]methyl}-1-piperidinyl)methylidenecarbamate

There total 8 articles about tert-butyl [(tert-butoxycarbonyl)amino](3-{[1-{[cyclohexyl(methyl)amino]carbonyl}-2-(2-naphthylsulfonyl)hydrazino]methyl}-1-piperidinyl)methylidenecarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 939796-71-1
N-cyclohexyl-N-methyl-2-(2-naphthylsulfonyl)-1-(3-piperidinylmethyl)-1-hydrazinecarboxamide

: 322474-21-5
N,N'-bis-Boc-S-methyl-isothiourea

: 939796-85-7
tert-butyl [(tert-butoxycarbonyl)amino](3-{[1-{[cyclohexyl(methyl)amino]carbonyl}-2-(2-naphthylsulfonyl)hydrazino]methyl}-1-piperidinyl)methylidenecarbamate

Guidance literature:: With triethylamine; mercury dichloride; In ethanol; at 20 ℃;
DOI:10.1691/ph.2007.4.6547

Reference yield:

: 500-22-1
3-pyridinecarboxaldehyde

: 939796-85-7
tert-butyl [(tert-butoxycarbonyl)amino](3-{[1-{[cyclohexyl(methyl)amino]carbonyl}-2-(2-naphthylsulfonyl)hydrazino]methyl}-1-piperidinyl)methylidenecarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 90 percent / ethanol / 4 h / Heating

2.1: 99 percent / H₂ / Pd/C / methanol / 50 °C / 37503.8 Torr

3.1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

3.2: CH₂Cl₂ / 0.25 h / 0 °C

3.3: 64 percent / CH₂Cl₂ / 0 - 20 °C

4.1: 83 percent / trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

5.1: 24 percent / Et₃N / CH₂Cl₂ / 72 h / 20 °C

6.1: 80 percent / aq. NaOH / dioxane / 4 h / Heating

7.1: 77 percent / Et₃N / HgCl₂ / ethanol / 20 °C

With sodium hydroxide; hydrogen; triethylamine; trifluoroacetic acid; palladium on activated charcoal; mercury dichloride; In 1,4-dioxane; methanol; ethanol; dichloromethane;
DOI:10.1691/ph.2007.4.6547

Reference yield:

: 939796-29-9
methyl 3-[(2-(tert-butoxycarbonyl)-1-{[cyclohexyl(methyl)amino]carbonyl}hydrazino)methyl]-1-piperidinecarboxylate

: 939796-85-7
tert-butyl [(tert-butoxycarbonyl)amino](3-{[1-{[cyclohexyl(methyl)amino]carbonyl}-2-(2-naphthylsulfonyl)hydrazino]methyl}-1-piperidinyl)methylidenecarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

2: 24 percent / Et₃N / CH₂Cl₂ / 72 h / 20 °C

3: 80 percent / aq. NaOH / dioxane / 4 h / Heating

4: 77 percent / Et₃N / HgCl₂ / ethanol / 20 °C

With sodium hydroxide; triethylamine; trifluoroacetic acid; mercury dichloride; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1691/ph.2007.4.6547