methyl 3-[(2-(tert-butoxycarbonyl)-1-{[cyclohexyl(methyl)amino]carbonyl}hydrazino)methyl]-1-piperidinecarboxylate

Base Information

Chemical Name:methyl 3-[(2-(tert-butoxycarbonyl)-1-{[cyclohexyl(methyl)amino]carbonyl}hydrazino)methyl]-1-piperidinecarboxylate
CAS No.:939796-29-9
Molecular Formula:C₂₁H₃₈N₄O₅
Molecular Weight:426.557
Hs Code.:

Synonyms:methyl 3-[(2-(tert-butoxycarbonyl)-1-{[cyclohexyl(methyl)amino]carbonyl}hydrazino)methyl]-1-piperidinecarboxylate

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Chemical Property of methyl 3-[(2-(tert-butoxycarbonyl)-1-{[cyclohexyl(methyl)amino]carbonyl}hydrazino)methyl]-1-piperidinecarboxylate

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Technology Process of methyl 3-[(2-(tert-butoxycarbonyl)-1-{[cyclohexyl(methyl)amino]carbonyl}hydrazino)methyl]-1-piperidinecarboxylate

There total 4 articles about methyl 3-[(2-(tert-butoxycarbonyl)-1-{[cyclohexyl(methyl)amino]carbonyl}hydrazino)methyl]-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 939796-15-3
tert-butyl 2-(3-piperidinylmethyl)-1-hydrazinecarboxylate

: 100-60-7
N-methylcyclohexylamine

: 32315-10-9
bis(trichloromethyl) carbonate

: 79-22-1
methyl chloroformate

: 939796-29-9
methyl 3-[(2-(tert-butoxycarbonyl)-1-{[cyclohexyl(methyl)amino]carbonyl}hydrazino)methyl]-1-piperidinecarboxylate

Guidance literature:: tert-butyl 2-(3-piperidinylmethyl)-1-hydrazinecarboxylate; methyl chloroformate; With triethylamine; In dichloromethane; at 0 ℃; for 1h;

bis(trichloromethyl) carbonate; In dichloromethane; at 0 ℃; for 0.25h;

N-methylcyclohexylamine; In dichloromethane; at 0 - 20 ℃; Further stages.;
DOI:10.1691/ph.2007.4.6547

Reference yield:

: 500-22-1
3-pyridinecarboxaldehyde

: 939796-29-9
methyl 3-[(2-(tert-butoxycarbonyl)-1-{[cyclohexyl(methyl)amino]carbonyl}hydrazino)methyl]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 90 percent / ethanol / 4 h / Heating

2.1: 99 percent / H₂ / Pd/C / methanol / 50 °C / 37503.8 Torr

3.1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

3.2: CH₂Cl₂ / 0.25 h / 0 °C

3.3: 64 percent / CH₂Cl₂ / 0 - 20 °C

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane;
DOI:10.1691/ph.2007.4.6547

Reference yield:

: tert-butyl 2-(3-pyridinylmeth-(E)-ylidene)-1-hydrazinecarboxylate

: 939796-29-9
methyl 3-[(2-(tert-butoxycarbonyl)-1-{[cyclohexyl(methyl)amino]carbonyl}hydrazino)methyl]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 99 percent / H₂ / Pd/C / methanol / 50 °C / 37503.8 Torr

2.1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

2.2: CH₂Cl₂ / 0.25 h / 0 °C

2.3: 64 percent / CH₂Cl₂ / 0 - 20 °C

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1691/ph.2007.4.6547